지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.9
- 수록면
- 196 - 205 (10page)
이용수
초록· 키워드
오류제보하기
Reactive oxygen species (ROS) generated from metabolic reactions cause oxidative DNA damage, which results in oxidative tissue injury. Therefore, there is an increasing demand in the intake of high antioxidant sources in order to maintain a healthy environment in cells. In this study, we investigated the antioxidant and anti-inflammatory activities of Malus domestica (apple), Pyrus communis L. (pear), Daucus carota L. (carrot), Brassica oleracea var. (broccoli), Brassica oleracea var. capitata (cabbage), and Raphanus sativus L. (radish) obtained from the local market. Since these are common fruits and vegetables that are widely consumed, we aimed to investigate their beneficial properties, placing particular emphasis on their antioxidant and anti-inflammatory properties. The samples were processed via an indirect heating method and their properties were compared to their raw forms. Based on DPPH and ABTS assays, processed samples showed better antioxidant activities when compared to raw samples and processed pear samples exhibited the best antioxidant activity. The anti-inflammatory activities of the samples were also investigated in LPS-treated RAW 264.7 cells. mRNA expression of pro-inflammatory mediators and cytokines (iNOS, COX-2, TNF-α, IL-1β, and IL-6) was assessed using RT-PCR. As expected, processed samples exhibited better iNOS inhibition when compared to their raw forms and processed broccoli and cabbage samples exhibited outstanding anti-inflammatory effects. The samples, up to 1 mg/mL concentration, did not exhibit cytotoxicity against RAW 264.7 cells as demonstrated by cell viability assays. Altogether, processed broccoli and cabbage samples exhibited the strongest anti-inflammatory properties.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (17)
참고문헌 신청
[학술지(정기간행물)] - Bayr H / 2005 / Reactive oxygen species / Critical Care Medicine 33 : 498 ~ 501
[학술지(정기간행물)] - Brand-Williams W / 1995 / Use of a free radical method to evaluate antioxidant activity / LWT-Food Science and Technology 28 : 25 ~ 30
[학술지(정기간행물)] - Dewanto V / 2002 / Thermal processing enhances the nutritional value of tomatoes by increasing total antioxidant activity / Journal of Agricultural and Food Chemistry 50 : 3010 ~ 3014
[학술지(정기간행물)] - Guzik T / 2003 / Nitric oxide and superoxide in inflammation / J Physiol Pharmacol 54 : 469 ~ 487
[학술지(정기간행물)] - Heo S-K / 2008 / Lps induces inflammatory responses in human aortic vascular smooth muscle cells via toll-like receptor 4 expression and nitric oxide production / Immunology Letters 120 : 57 ~ 64
[학술지(정기간행물)] - Brand-Williams W / 1995 / Use of a free radical method to evaluate antioxidant activity / LWT-Food Science and Technology 28 : 25 ~ 30
[학술지(정기간행물)] - Dewanto V / 2002 / Thermal processing enhances the nutritional value of tomatoes by increasing total antioxidant activity / Journal of Agricultural and Food Chemistry 50 : 3010 ~ 3014
[학술지(정기간행물)] - Guzik T / 2003 / Nitric oxide and superoxide in inflammation / J Physiol Pharmacol 54 : 469 ~ 487
[학술지(정기간행물)] - Heo S-K / 2008 / Lps induces inflammatory responses in human aortic vascular smooth muscle cells via toll-like receptor 4 expression and nitric oxide production / Immunology Letters 120 : 57 ~ 64
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UCI(KEPA) : I410-ECN-0101-2018-510-003599324