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논문 기본 정보

자료유형
학술저널
저자정보
김학령 (서울대학교) Jaehoon Chung (National Medical Center) 한석문 (서울대학교병원) Hyun Sung Joh (Seoul Metropolitan Government Seoul National University Boramae Medical Center)
저널정보
대한고혈압학회 Clinical Hypertension Clinical Hypertension 제29권
발행연도
2023.1
수록면
8 - 8 (1page)

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Background Little is known about the characteristics of arterial stifness in heart failure (HF). This study was per‑ formed to compare the degree of arterial stifness and its association with left ventricular (LV) diastolic function among three groups: control subjects, patients with HF with reduced ejection fraction (HFrEF), and patients with HF with preserved ejection fraction (HFpEF). Methods A total of 83 patients with HFrEF, 68 patients with HFpEF, and 84 control subjects were analyzed. All HF patients had a history of hospitalization for HF treatment. Brachial-ankle pulse wave velocity (baPWV) measurement and transthoracic echocardiography were performed at the same day in a stable condition. Results The baPWV was signifcantly higher in patients with both HFrEF and HFpEF compared to control subjects (1,661±390, 1,909±466, and 1,477±296 cm/sec, respectively; P<0.05 for each). After adjustment of age, baPWV val‑ ues were similar between patients with HFrEF and HFpEF (P=0.948). In the multiple linear regression analysis, baPWV was signifcantly associated with both septal e′ velocity (β=–0.360, P=0.001) and E/e′ (β=0.344, P=0.001). How‑ ever, baPWV was not associated with either of the diastolic indices in HFrEF group. The baPWV was associated only with septal e′ velocity (β=–0.429, P=0.002) but not with E/e′ in the HFpEF group in the same multivariable analysis. Conclusions Although arterial stifness was increased, its association with LV diastolic function was attenuated in HF patients compared to control subjects. The degree of arterial stifening was similar between HFrEF and HFpEF.

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