지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 306 - 315 (10page)
이용수
초록· 키워드
오류제보하기
Background: The level of Galectin-3 (Gal-3) protein purportedly reflects an ongoing cardiac fibrotic process and has been associated with ventricular remodeling, which is instrumental in the development of heart failure with preserved ejection fraction (HFpEF) syndrome. The aim of this study was to investigate the potential use of Gal-3 in improved characterization of the grades of diastolic dysfunction as defined by echocardiography. Methods: Seventy HFpEF patients undergoing routine echocardiography were prospectively enrolled in the present monocentric study. Blood samples for measurements of Gal-3 and amino-terminal pro-brain natriuretic peptide (NT-proBNP) were collected within 24 hours pre- or post-echocardiographic examination. The classification of patients into subgroups based on diastolic dysfunction grade permitted detailed statistical analyses of the derived data. Results: The Gal-3 serum levels of all patients corresponded to echocardiographic indices, suggesting HFpEF (E/A, P =0.03 and E/E’, P =0.02). Gal-3 was also associated with progressive diastolic dysfunction, and increased levels corresponded to the course of disease (P =0.012). Detailed analyses of ROC curves suggested that Gal-3 levels could discriminate patients with grade III diastolic dysfunction (area under the curve [AUC]=0.770, P =0.005). Conclusions: Gal-3 demonstrates remarkable effectiveness in the diagnosis of patients suffering from severe grade diastolic dysfunction. Increasing levels of Gal-3 possibly reflect the progressive course of HFpEF, as classified by the echocardiographic grades of diastolic dysfunction.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Go AS / 2014 / Heart disease and stroke statistics--2014 update: a report from the American Heart Association / Circulation 129:28~292
McMurray JJ / 2012 / ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC / Eur Heart J 33:1787~1847
Cheng JM / 2013 / Biomarkers of heart failure with normal ejection fraction: a systematic review / Eur J Heart Fail 15:1350~1362
de Boer RA / 2013 / Galectin-3 in heart failure with preserved ejection fraction / Eur J Heart Fail 15:1095~1101
Tribouilloy C / 2008 / Prognosis of heart failure with preserved ejection fraction: a 5 year prospective population-based study / Eur Heart J 29:339~347
McMurray JJ / 2012 / ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC / Eur Heart J 33:1787~1847
Cheng JM / 2013 / Biomarkers of heart failure with normal ejection fraction: a systematic review / Eur J Heart Fail 15:1350~1362
de Boer RA / 2013 / Galectin-3 in heart failure with preserved ejection fraction / Eur J Heart Fail 15:1095~1101
Tribouilloy C / 2008 / Prognosis of heart failure with preserved ejection fraction: a 5 year prospective population-based study / Eur Heart J 29:339~347
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