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Impact of Airway Virus in Severe Asthmatic Patients: A Pilot Study
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Type
Academic journal
Author
Walsh Laura J (Department of Respiratory Medicine Cork University Hospital Cork Ireland.) Sullivan Ashley (The APC Microbiome Ireland University College Cork Cork Ireland.The Schools of Medicine and Microbiology University College Cork Cork Ireland.) Ward Christopher (Translational and Clinical Research Institute Newcastle University Newcastle upon Tyne UK.)
Journal
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.15 No.3 KCI Accredited Journals
Published
2023.5
Pages
406 - 411 (6page)
DOI
10.4168/aair.2023.15.3.406

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Impact of Airway Virus in Severe Asthmatic Patients: A Pilot Study
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The lungs have their own microbiota which seems to be altered in disease processes such as asthma. Viral infection accounts for many asthma exacerbations. Little is known about the lung virome, and the role that viruses play in non-exacerbating asthmatics. We aimed to assess if detection of virus in bronchoscopy samples of asthmatic patients in a non-exacerbating state influences their asthma control and modulates airway cytokine composition. Patients were recruited from a specialist asthma clinic and underwent bronchoscopy with standardised bronchoalveolar lavage (BAL). Viral analysis was performed; cell differential and cytokine levels were measured. Forty-six samples were obtained of which 10.8% demonstrated evidence of airway virus, and 91.3% of patients in the cohort were classed as severe asthmatics. Oral steroid use was significantly higher in severe asthmatic patients with virus detected, and the forced expiratory volume in one second tended to be lower in the virus-detected group. It was also found that BAL interleukin-13 and tumor necrosis factor-α levels were significantly higher in severe asthmatic patients with virus detected. Our results suggest that in severe asthmatics in a non-exacerbating state, the presence of virus resulted in overall poorer asthma control. The pattern of cytokine elevation seen in asthmatic patients with virus detected may provide insight to the pathophysiology involved.
#Asthma #microbiota #virome #asthma exacerbation #viruses #bronchoscopy #cytokines #bronchoalveolar lavage #tumor necrosis factor

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