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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.12 No.1
- 발행연도
- 2020.1
- 수록면
- 4 - 23 (20page)
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초록· 키워드
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MicroRNAs (miRs) are single-stranded RNAs of 18-25 nucleotides. These molecules regulate gene expression at the post-transcriptional level; several of these are differentially expressed in asthma as well as in viral acute respiratory infections (ARIs), the main triggers of acute asthma exacerbations. In recent years, miRs have been studied in order to discover drug targets as well as biomarkers for diagnosis, disease severity and prognosis. We describe recent findings on miR expression and function in asthma and their role in the regulation of viral ARIs, according to cell tissue specificity and asthma severity. By combining the above information, we identify miRs that may be important in virus-induced asthma exacerbations. This is the first attempt to link miR profiles of asthmatic patients and ARI-induced miRs, addressing the question of whether there might be a specific miR deficit in asthmatic subjects that make them more susceptible and/or reactive to infection.
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참고문헌 (113)
참고문헌 신청
Kingsley SM / 2017 / Role of microRNAs in sepsis / Inflamm Res 66:553~569
Mogensen TH / 2009 / Pathogen recognition and inflammatory signaling in innate immune defenses / Clin Microbiol Rev 22:240~273
Drury RE / 2017 / The clinical application of microRNAs in infectious disease / Front Immunol 8:1182
Pua HH / 2015 / MicroRNA regulation of allergic inflammation and asthma / Curr Opin Immunol 36:101~108
Karin M / 2009 / Innate immunity gone awry : linking microbial infections to chronic6. Bartel DP. MicroRNAs : target recognition and regulatory functions / Cell 136:215~233
Mogensen TH / 2009 / Pathogen recognition and inflammatory signaling in innate immune defenses / Clin Microbiol Rev 22:240~273
Drury RE / 2017 / The clinical application of microRNAs in infectious disease / Front Immunol 8:1182
Pua HH / 2015 / MicroRNA regulation of allergic inflammation and asthma / Curr Opin Immunol 36:101~108
Karin M / 2009 / Innate immunity gone awry : linking microbial infections to chronic6. Bartel DP. MicroRNAs : target recognition and regulatory functions / Cell 136:215~233
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