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논문 기본 정보

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학술저널
저자정보
Chen Shoucheng (Hospital of Stomatology Guanghua School of Stomatology Sun Yat-Sen University and Guangdong Provincial Key Laboratory of Stomatology) Huang Zhuwei (Hospital of Stomatology Guanghua School of Stomatology Sun Yat-Sen University and Guangdong Provincial Key Laboratory of Stomatology) Visalakshan Rahul Madathiparambil (Oregon Health & Science University Portland) Liu Haiwen (Hospital of Stomatology Guanghua School of Stomatology Sun Yat-Sen University and Guangdong Provincial Key Laboratory of Stomatology) Bachhuka Akash (Department of Electronics Electric and Automatic Engineering Rovira i Virgili University (URV)) Wu You (Hospital of Stomatology Guanghua School of Stomatology Sun Yat-Sen University and Guangdong Provincial Key Laboratory of Stomatology) Dabare Panthihage Ruvini L. (Academic Unit of Science Technology Engineering and Mathematics (STEM) University of South Australia) Luo Pu (Hospital of Stomatology Guanghua School of Stomatology Sun Yat-Sen University and Guangdong Provincial Key Laboratory of Stomatology) Liu Runheng (Hospital of Stomatology Guanghua School of Stomatology Sun Yat-Sen University and Guangdong Provincial Key Laboratory of Stomatology) Gong Zhuohong (Hospital of Stomatology Guanghua School of Stomatology Sun Yat-Sen University and Guangdong Provincial Key Laboratory of Stomatology) Xiao Yin (Institute of Health and Biomedical Innovation Queensland University of Technology) Vasilev Krasimir (Academic Unit of Science Technology Engineering and Mathematics (STEM) University of South Australia) Chen Zhuofan (Hospital of Stomatology Guanghua School of Stomatology Sun Yat-Sen University and Guangdong Provincial Key Laboratory of Stomatology) Chen Zetao (Hospital of Stomatology Guanghua School of Stomatology Sun Yat-Sen University and Guangdong Provincial Key Laboratory of Stomatology)
저널정보
한국생체재료학회 생체재료학회지 생체재료학회지 제27권
발행연도
2023.3
수록면
282 - 302 (21page)
DOI
10.1186/s40824-022-00323-0

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Background : Transepithelial medical devices are increasing utilized in clinical practices. However, the damage of continuous natural epithelial barrier has become a major risk factor for the failure of epithelium-penetrating implants. How to increase the “epithelial barrier structures” (focal adhesions, hemidesmosomes, etc.) becomes one key research aim in overcoming this difficulty. Directly targeting the in situ “epithelial barrier structures” related proteins (such as fibronectin) absorption and functionalization can be a promising way to enhance interface-epithelial integration. Methods : Herein, we fabricated three plasma polymerized bio-interfaces possessing controllable surface chemistry. Their capacity to adsorb and functionalize fibronectin (FN) from serum protein was compared by Liquid Chromatography-Tandem Mass Spectrometry. The underlying mechanisms were revealed by molecular dynamics simulation. The response of gingival epithelial cells regarding the formation of epithelial barrier structures was tested. Results : Plasma polymerized surfaces successfully directed distinguished protein adsorption profiles from serum protein pool, in which plasma polymerized allylamine (ppAA) surface favored adsorbing adhesion related proteins and could promote FN absorption and functionalization via electrostatic interactions and hydrogen bonds, thus subsequently activating the ITG β1-FAK-mTOR signaling and promoting gingival epithelial cells adhesion. Conclusion : This study offers an effective perspective to overcome the current dilemma of the inferior interface-epithelial integration by in situ protein absorption and functionalization, which may advance the development of functional transepithelial biointerfaces. Graphical Abstract : Tuning the surface chemistry by plasma polymerization can control the adsorption of fibronectin and functionalize it by exposing functional protein domains. The functionalized fibronectin can bind to human gingival epithelial cell membrane integrins to activate epithelial barrier structure related signaling pathway, which eventually enhances the formation of epithelial barrier structure.
#Transepithelial medical devices #Plasma polymerization #Epithelial barrier structure #Protein adsorption

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