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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 11 - 17 (7page)
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The gingival epithelium of the oral cavity is constantlyexposed to exogenous stimuli such as bacterial toxins,allergens, and thermal changes. These exogenous stimuli areresisted by innate host defense in gingival epithelial cells.
However, it is unclear exactly how the exogenous stimuliaffect detrimentally on the human gingival epithelial cells.
Here, we investigated whether the allergen, such as house dustmite (HDM) extract, is linked to Ca2+ signaling and proinflammatorycytokine expression in primary cultured humangingival epithelial cells. HDM extract induced an increase inintracellular Ca2+ concentration ([Ca2+]i) in a dose-dependentmanner. Extracellular Ca2+ depletion did not affected on theHDM extract-induced increase in [Ca2+]i. The HDM extractinducedincrease in [Ca2+]i was abolished by the treatmentwith U73122 and 2-APB, which are inhibitors ofphospholipase C (PLC) and inositol 1,4,5-trisphosphate (IP3)receptor. Moreover, HDM extract induced the mRNAexpression of pro-inflammatory cytokine, interleukin (IL)-8.
These results suggest that HDM extract triggers PLC/IP3-dependent Ca2+ signaling and IL-8 mRNA expression inprimary cultured human gingival epithelial cells.
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참고문헌 (25)
참고문헌 신청
Belton CM / 2004 / Calcium oscillations in gingival epithelial cells infected with Porphyromonas gingivalis / Microbes and Infection 6(5):440~447
Makoto Oikawa / 2013 / Effects of protease-activated receptors (PARs) on intracellular calcium dynamics of acinar cells in rat lacrimal glands / Histochemistry and Cell Biology 140(4):463~476
M. G. Lee / 2012 / Molecular Mechanism of Pancreatic and Salivary Gland Fluid and HCOFormula Secretion / Physiological Reviews 92(1):39~74
J. Chun / 2006 / Activation of Ca2+-Dependent Signaling by TLR2 / The Journal of Immunology 177(2):1330~1337
Adam E / 2006 / The house dust mite allergen Der p 1, unlike Der p 3, stimulates the expression of interleukin-8 in human airway epithelial cells via a proteinase-activated r
Makoto Oikawa / 2013 / Effects of protease-activated receptors (PARs) on intracellular calcium dynamics of acinar cells in rat lacrimal glands / Histochemistry and Cell Biology 140(4):463~476
M. G. Lee / 2012 / Molecular Mechanism of Pancreatic and Salivary Gland Fluid and HCOFormula Secretion / Physiological Reviews 92(1):39~74
J. Chun / 2006 / Activation of Ca2+-Dependent Signaling by TLR2 / The Journal of Immunology 177(2):1330~1337
Adam E / 2006 / The house dust mite allergen Der p 1, unlike Der p 3, stimulates the expression of interleukin-8 in human airway epithelial cells via a proteinase-activated r
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