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Pravastatin mitigates radiation-induced enteropathy by enhancing epithelial integrity
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논문 기본 정보

Type
Proceeding
Author
Seo Young Kwak (Korea Institute of Radiological and Medical Sciences) Hyewon Kim (Korea Institute of Radiological and Medical Sciences) Sehwan Shim (Korea Institute of Radiological and Medical Sciences) Hyosun Jang (Korea Institute of Radiological and Medical Sciences)
Journal
Korean Association for Laboratory Animal Science 한국실험동물학회 학술발표대회 논문집 2021 KALAS International Symposium
Published
2021.7
Pages
185 - 185 (1page)

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Pravastatin mitigates radiation-induced enteropathy by enhancing epithelial integrity
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Radiotherapy or accidental exposure to ionizing radiation causes severe damage of healthy intestinal tissues. Intestinal barrier function is highly sensitive to ionizing radiation, and loss of epithelial integrity results in mucosal inflammation, bacterial translocation, and endotoxemia. The minipig model is a suitable model for evaluation of pharmaceutical oral bioavailability. Using this model, we found that pravastatin (PS) mitigated acute radiation-induced enteropathy. PS-treated irradiated minipigs had mild clinical symptoms, lower intestinal inflammation and endotoxin levels, and improved gastrointestinal integrity, compared with control group animals. The results of mRNA sequencing analysis indicated that PS treatment ma ... View All
#Pravastatin #Minipig model #Epithelial integrity #Radiation-induced enteropathy

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