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논문 기본 정보

자료유형
학술저널
저자정보
Huifang Wang (Shenzhen Institute of Respiratory Disease Shenzhen Clinical Research Centre for Respirology The Second Clinical Medical College The First Affiliated Hospital Shenzhen People’s Hospital Jinan Universit) Runhua Zhou (School of Pharmaceutical Science Southern Medical University) Fushan Xu (The Second Clinical Medical College The First Affiliated Hospital Shenzhen People’s Hospital Jinan University Southern University of Science and Technology) Kongjun Yang (The Second Clinical Medical College The First Affiliated Hospital Shenzhen People’s Hospital Jinan University Southern University of Science and Technology) Liuhai Zheng (Shenzhen Institute of Respiratory Disease Shenzhen Clinical Research Centre for Respirology The Second Clinical Medical College The First Affiliated Hospital Shenzhen People’s Hospital Jinan Universit) Pan Zhao (Shenzhen Institute of Respiratory Disease Shenzhen Clinical Research Centre for Respirology The Second Clinical Medical College The First Affiliated Hospital Shenzhen People’s Hospital Jinan Universit) Guangwei Shi (School of Pharmaceutical Science Southern Medical University) Lingyun Dai (Shenzhen Institute of Respiratory Disease Shenzhen Clinical Research Centre for Respirology The Second Clinical Medical College The First Affiliated Hospital Shenzhen People’s Hospital Jinan Universit) Chengchao Xu (Shenzhen Institute of Respiratory Disease Shenzhen Clinical Research Centre for Respirology The Second Clinical Medical College The First Affiliated Hospital Shenzhen People’s Hospital Jinan Universit) Le Yu (School of Pharmaceutical Science Southern Medical University) Zhijie Li (Shenzhen Institute of Respiratory Disease Shenzhen Clinical Research Centre for Respirology The Second Clinical Medical College The First Affiliated Hospital Shenzhen People’s Hospital Jinan Universit) Jianhong Wang (Shenzhen Mental Health Center Shenzhen Kangning Hospital) Jigang Wang (Shenzhen Institute of Respiratory Disease Shenzhen Clinical Research Centre for Respirology The Second Clinical Medical College The First Affiliated Hospital Shenzhen People’s Hospital Jinan Universit)
저널정보
한국생체재료학회 생체재료학회지 생체재료학회지 제27권
발행연도
2023.3
수록면
1,785 - 1,812 (28page)
DOI
https://doi.org/10.1186/s40824-023-00385-8

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Targeted protein degradation (TPD) is an emerging therapeutic strategy with the potential to modulate disease associated proteins that have previously been considered undruggable, by employing the host destructionmachinery. The exploration and discovery of cellular degradation pathways, including but not limited toproteasomes and lysosome pathways as well as their degraders, is an area of active research. Since the conceptof proteolysis-targeting chimeras (PROTACs) was introduced in 2001, the paradigm of TPD has been greatlyexpanded and moved from academia to industry for clinical translation, with small-molecule TPD being particularlyrepresented. As an indispensable part of TPD, biological TPD (bioTPD) technologies including peptide-, fusionprotein-, antibody-, nucleic acid-based bioTPD and others have also emerged and undergone significantadvancement in recent years, demonstrating unique and promising activities beyond those of conventional small molecule TPD. In this review, we provide an overview of recent advances in bioTPD technologies, summarize theircompositional features and potential applications, and briefly discuss their drawbacks. Moreover, we present somestrategies to improve the delivery efficacy of bioTPD, addressing their challenges in further clinical development.
#Biological targeted protein degradation (bioTPD) #Peptide #Antibody #Fusion protein #Nucleic acid

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