지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.3
- 수록면
- 36 - 43 (8page)
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초록· 키워드
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Nuclear targeting of bacterial proteins in host cells and subsequent interaction with nuclear molecules are an emerging pathogenic mechanism of bacteria. In this study, we predicted the nuclear targeting proteins with nuclear localization signals (NLSs) in Staphylococcus aureus using bioinformatic analysis. A total of 51 proteins of S. aureus, comprising of 24 functional and 27 hypothetical proteins, were predicted to carry putative NLSs. Among them, β-lactamase and MsrR proteins with the putative NLSs were selected to determine the nuclear targeting in host cells. Fusion proteins of BlaZ-green fluorescent protein (GFP) were evenly distributed in the nuclei of host cells and subsequently induced host cell death. However, fusion proteins of MsrR-GFP were not localized in the nuclei of host cells In conclusion, screening of nuclear targeting proteins with NLSs and determination of their pathology in host cells may open up the new field of S. aureus pathogenesis.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (28)
참고문헌 신청
1. [학술지(정기간행물)] - Matarrese P / 2007 / Clostridium difficile toxin B causes apoptosis in epithelial cells by thrilling mitochondria. Involvement of ATP-sensitive mitochondrial potassium channels / J Biol Chem 282 : 9029 ~ 9041
2. [학술지(정기간행물)] - Müller A / 2000 / Targeting of the pro-apoptotic VDAC-like porin (PorB) of Neisseria gonorrhoeae to mitochondria of infected cells / EMBO J 19 : 5332 ~ 5343
3. [학술지(정기간행물)] - Nagai T / 2005 / Targeting of enteropathogenic Escherichia coli EspF to host mitochondria is essential for bacterial pathogenesis: critical role of the 16th leucine residue in EspF / J Biol Chem 280 : 2998 ~ 3011
4. [학술지(정기간행물)] - Nougayrède JP / 2004 / Enteropathogenic Escherichia coli EspF is targeted to mitochondria and is required to initiate the mitochondrial death pathway / Cell Microbiol 6 : 1097 ~ 1111
5. [학술지(정기간행물)] - Papatheodorou P / 2006 / The enteropathogenic Escherichia coli (EPEC) Map effector is imported into the mitochondrial matrix by the TOM/Hsp70 system and alters organelle morphology / Cell Microbiol 8 : 677 ~ 689
2. [학술지(정기간행물)] - Müller A / 2000 / Targeting of the pro-apoptotic VDAC-like porin (PorB) of Neisseria gonorrhoeae to mitochondria of infected cells / EMBO J 19 : 5332 ~ 5343
3. [학술지(정기간행물)] - Nagai T / 2005 / Targeting of enteropathogenic Escherichia coli EspF to host mitochondria is essential for bacterial pathogenesis: critical role of the 16th leucine residue in EspF / J Biol Chem 280 : 2998 ~ 3011
4. [학술지(정기간행물)] - Nougayrède JP / 2004 / Enteropathogenic Escherichia coli EspF is targeted to mitochondria and is required to initiate the mitochondrial death pathway / Cell Microbiol 6 : 1097 ~ 1111
5. [학술지(정기간행물)] - Papatheodorou P / 2006 / The enteropathogenic Escherichia coli (EPEC) Map effector is imported into the mitochondrial matrix by the TOM/Hsp70 system and alters organelle morphology / Cell Microbiol 8 : 677 ~ 689
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