Exercise Capacity and Pulmonary Capacitance Are Attenuated in Patients with Nonalcoholic Steatohepatitis

Donkor Joshua; Carlson Alex R.; Ziegler Briana L.; Johnston Jessica I.; Cho Jinkyung; Johnson Bruce D.; Kim Chul-Ho

doi:10.5763/kjsm.2023.41.2.107

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자료유형: 학술저널

저자정보: Donkor Joshua (Department of Cardiovascular Disease Mayo Clinic Rochester MN USA) Carlson Alex R. (Department of Cardiovascular Disease Mayo Clinic Rochester MN USA) Ziegler Briana L. (Department of Cardiovascular Disease Mayo Clinic Rochester MN USA) Johnston Jessica I. (Department of Cardiovascular Disease Mayo Clinic Rochester MN USA) Cho Jinkyung (Department of Cardiovascular Disease Mayo Clinic Rochester MN USA) Johnson Bruce D. (Department of Cardiovascular Disease Mayo Clinic Rochester MN USA) Kim Chul-Ho (Department of Cardiovascular Disease Mayo Clinic Rochester MN USA)

저널정보: 대한스포츠의학회 대한스포츠의학회지 대한스포츠의학회지 제41권 제2호

발행연도: 2023.6

수록면: 107 - 110 (4page)

DOI: 10.5763/kjsm.2023.41.2.107

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Purpose: The study was to investigate exercise capacity (peak oxygen uptake [peak VO2]) and pulmonary capacitance (GXcap), which is an estimate of pulmonary vascular capacitance, in patients with nonalcoholic steatohepatitis (NASH). Methods: This study utilized a database of patients with NASH (n=26 [17 male and 9 female], aged 58.9±4.3 years) and healthy individuals (n=23 [12 male and 11 female, aged 58.6±7.9 years) who underwent a maximal exercise test on a recumbent cycle ergometer (Corival; Lode) in our laboratory. During cardiopulmonary exercise tests, breathing patterns and respiratory gas exchange including breathing efficiency (VE/VCO2) and end-tidal CO2 (PETCO2) were measured. In addition, peak VO2 was obtained via averaging the last 30 seconds at peak level and GXcap was obtained by calculation as follows: GXcap=oxygen pulse (O2 pulse)×PETCO2. Results: The NASH group demonstrated reduced peak VO2 relative to the healthy group (17.5±8.4 mL/kg/min vs. 34±10.2 mL/kg/min, respectively; p＜0.05). In addition, there was a higher VE/VCO2 relationship in the NASH group relative to the healthy group (34.9±5.5 vs. 32.2±4.0, respectively; p＜0.05) and lower PETCO2 in the NASH group compared to the healthy group (32.8±4.0 mm Hg vs. 35.3±3.8 mm Hg, respectively; p＜0.05). Furthermore, the NASH group showed lower GXcap than the healthy group (456±150 vs. 551±202, respectively; p＜0.05). Conclusion: Patients with NASH had reduced exercise capacity and pulmonary vascular capacitance relative to age-matched healthy adults and this may contribute to pulmonary pathophysiology in NASH.

#Non-alcoholic fatty liver disease #Pulmonary capacitance #Exercise capacity

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