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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제51권 제2호
- 발행연도
- 2021.1
- 수록면
- 183 - 197 (15page)
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Purpose Our research aims to address and determine the effect of Camellia sinensis extract in the management of nonalcoholic steatohepatitis (NASH) in rats. Methods Forty adult female albino rats were divided into four groups. Group 1 (G1) served as the control group, while the other three groups received high-fat diet for 32 weeks to induce NASH and then were later assigned to the following groups: (G2) NASH-afflicted group which was left untreated, (G3) NASH-afflicted group treated with Camellia sinensis extract in a dose of 400 mg/kg, and (G4) NASH-afflicted group treated with Camellia sinensis extract in a dose of 200 mg/kg. Results Significant elevation in serum alanine aminotransferase, albumin, bilirubin (total and direct), cholesterol, low density lipoprotein, triglycerides, leptin, Cox-2, and CD40 values was recorded. Moreover, overexpression of hepatic tumor necrosis factor alpha and hepatocyte growth factor genes were recorded, whereas blood platelet count and serum high density lipoprotein concentration revealed significant depletion, which was paralleled by significant downregulation of hepatic adiponectin gene expression level in NASH group versus the control group. On the opposite side, treatment of NASH groups with two different doses of Camellia sinensis extract reversed the values of the measured biochemical parameters and the targeted gene expression levels when compared with the NASH group. Optical micrograph of liver tissue sections of rats treated with Camellia sinensis extract showed the observed improvement in the studied biochemical and genetic markers. Conclusion This study provides a clear evidence for the promising therapeutic potential of Camellia sinensis extract against NASH. This could be ascribed to its hepatoprotective activity, hypolipidemic effect, and anti-inflammatory potency.
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참고문헌 (96)
참고문헌 신청
Abdul Aziz M / 2018 / Traditional uses of medicinal plants practiced by the indigenous communities at Mohmand Agency, FATA. Pak / J Ethnobiol Ethnomed 14:2
Adams LA / 2005 / The natural history of nonalcoholic fatty liver disease: a population-based cohort study / Gastroenterology 129:113~121
Ali FK / 2008 / Efect of water pollution on expression of immune response genes of Soleaaegyptiaca in Lake Qarun / Afr J Biotech 7:1418~1425
Allain CC / 1974 / Enzymatic determination of total serum cholesterol / Clin Chem 20:470~475
Amirtharaj GJ / 2008 / Fatty acids infuence binding of cobalt to serum albumin in patients with fatty liver / Biochimica et Biophysica Acta (BBA) 1782:349~354
Adams LA / 2005 / The natural history of nonalcoholic fatty liver disease: a population-based cohort study / Gastroenterology 129:113~121
Ali FK / 2008 / Efect of water pollution on expression of immune response genes of Soleaaegyptiaca in Lake Qarun / Afr J Biotech 7:1418~1425
Allain CC / 1974 / Enzymatic determination of total serum cholesterol / Clin Chem 20:470~475
Amirtharaj GJ / 2008 / Fatty acids infuence binding of cobalt to serum albumin in patients with fatty liver / Biochimica et Biophysica Acta (BBA) 1782:349~354
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