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논문 기본 정보

자료유형
학술저널
저자정보
Kim Jisoo (Department of Radiology and Research Institute of Radiological Science Severance Hospital Yonsei University College of Medicine Seoul Korea.) Yoon Haesung (Department of Radiology and Research Institute of Radiological Science Severance Hospital Yonsei University College of Medicine Seoul Korea.) Lim Hyun Ji (Department of Radiology and Research Institute of Radiological Science Severance Hospital Yonsei University College of Medicine Seoul Korea.) Kim Hyun Woo (Division of Pediatric Orthopaedic Surgery Severance Children’s Hospital Yonsei University College of Medicine Seoul Korea.) Suk Yong June (Division of Pediatric Orthopaedic Surgery Severance Children’s Hospital Yonsei University College of Medicine Seoul Korea.) Park Kun-Bo (Division of Pediatric Orthopaedic Surgery Severance Children’s Hospital Yonsei University College of Medicine Seoul Korea.) Lee Mi-Jung (Department of Radiology and Research Institute of Radiological Science Severance Hospital Yonsei University College of Medicine Seoul Korea.)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.38 No.21
발행연도
2023.5
수록면
1 - 10 (10page)
DOI
10.3346/jkms.2023.38.e187

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Background: Sarcopenia can be associated with the disease etiologies other than degenerative processes, such as neurologic disease including cerebral palsy, myelomeningocele, or Duchenne muscular dystrophy, even in children. Although the relationship between neurologic disease and scoliosis or ambulatory function is known, the mediators affecting scoliosis or gait function in these patients are unclear, an example might be sarcopenia. This study aimed to assess the degree of sarcopenia in young patients with neurologic diseases using computed tomography (CT), and analyze the correlation between sarcopenia and scoliosis or ambulatory function. Methods: Pediatric and young adult patients (≤ 25 years old) who underwent whole-spine or lower-extremity CT were retrospectively included. From bilateral psoas muscle areas (PMAs) at the L3 level, the psoas muscle z-score (PMz) and psoas muscle index [PMI = PMA/(L3 height)2 ] were calculated. The t-test, Fisher’s exact test, and logistic regression analyses were performed. Results: A total of 121 patients (56 men, mean age 12.2 ± 3.7 years) were included with 79 neurologic and 42 non-neurologic diseases. Patients with neurologic diseases had lower PMz (P = 0.013) and PMI (P = 0.026) than patients without. In neurologic disease patients, severe scoliosis patients showed lower PMz (P < 0.001) and PMI (P = 0.001). Non-ambulatory patients (n = 42) showed lower BMI (β = 0.727, P < 0.001) and PMz (β = 0.547, P = 0.025). In non-ambulatory patients, patients with severe scoliosis also showed lower PMz (P < 0.001) and PMI (P = 0.004). Conclusion: Patients with neurologic diseases could have sarcopenia even in young age. Psoas muscle volume was also associated with ambulatory function in these patients. Sarcopenia was more severe in severe scoliosis patients in the non-ambulatory subgroup.

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