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학술저널
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이윤임 (단국대학교 의과대학 내과학교실) Ko Ryoung-Eun (Department of Critical Care Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea.) 나수진 (Department of Critical Care Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea) Ryu Jeong-Am (Samsung Medical Center) Cho Yang Hyun (Department of Thoracic and Cardiovascular Surgery Samsung Medical Center School of Medicine Sungkyunkwan University Seoul Korea.) 양정훈 (삼성서울병원) 정치량 (성균관대학교) 서지영 (성균관대학교)
저널정보
대한중환자의학회 Acute and Critical Care Acute and Critical Care 제38권 제2호
발행연도
2023.5
수록면
190 - 199 (10page)
DOI
10.4266/acc.2022.01438

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Background Respiratory quotient (RQ) may be used as a tissue hypoxia marker in various clinical settings but its prognostic significance in patients undergoing extracorporeal cardiopulmonary resuscitation (ECPR) is not known. Methods Medical records of adult patients admitted to the intensive care units after ECPR in whom RQ could be calculated from May 2004 to April 2020 were retrospectively reviewed. Patients were divided into good neurologic outcome and poor neurologic outcome groups. Prognostic significance of RQ was compared to other clinical characteristics and markers of tissue hypoxia. Results During the study period, 155 patients were eligible for analysis. Of them, 90 (58.1%) had a poor neurologic outcome. The group with poor neurologic outcome had a higher incidence of out-of-hospital cardiac arrest (25.6% vs. 9.2%, P=0.010) and longer cardiopulmonary resuscitation to pump-on time (33.0 vs. 25.2 minutes, P=0.001) than the group with good neurologic outcome. For tissue hypoxia markers, the group with poor neurologic outcome had higher RQ (2.2 vs. 1.7, P=0.021) and lactate levels (8.2 vs. 5.4 mmol/L, P=0.004) than the group with good neurologic outcome. On multivariable analysis, age, cardiopulmonary resuscitation to pump-on time, and lactate levels above 7.1 mmol/L were significant predictors for a poor neurologic outcome but not RQ. Conclusions In patients who received ECPR, RQ was not independently associated with poor neurologic outcome.

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