A mechanism-based understanding of altered drug pharmacokinetics by gut microbiota

Gulnaz Aneela; Chang Ji-Eun; Maeng Han-Joo; Shin Kwang-Hee; Lee Kyeong-Ryoon; Chae Yoon-Jee

doi:10.1007/s40005-022-00600-z

A mechanism-based understanding of altered drug pharmacokinetics by gut microbiota

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Type: Academic journal

Author: Gulnaz Aneela (College of Pharmacy Woosuk University) Chang Ji-Eun (Dongduk Women’s University) Maeng Han-Joo (가천대학교) Shin Kwang-Hee (Kyungpook National University) Lee Kyeong-Ryoon (Korea Research Institute of Bioscience and Biotechnology) Chae Yoon-Jee (College of Pharmacy Woosuk University)

Journal: Korean Society of Pharmaceutical Science and Technology Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제53권 제1호 KCI Accredited Journals

Published: 2023.1

Pages: 73 - 92 (20page)

DOI: 10.1007/s40005-022-00600-z

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A mechanism-based understanding of altered drug pharmacokinetics by gut microbiota

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Background Pharmacomicrobiomics, which has recently emerged as a new strategy for personalized medicine, is the investigation of the influence of microbial variability on drug pharmacokinetics, efficacy, and safety. The roles of gut microbiota in drug pharmacokinetics should be thoroughly investigated, given the significant implications of gut microbiota in humans. Area covered In this paper, we provide a mechanism-based review of the impact of the gut microbiota on drug pharmacokinetics, primarily based on drug metabolism and transporters. The main mechanisms presented here are the direct metabolism of drugs by gut microbiota activity, modulation of relevant gene expression, and competitive inhibition using their metabolites. We also present the limitations of current research and provide perspectives for future investigations. Expert opinion Although prominent advances in research have paved the way to link gut microbiota and drug pharmacokinetics, there are still some limitations and restrictions to understand their intricate association. Particular attention should be paid to studies using germ-free or antibiotic-treated animals to determine associations between gut microbiota and drug pharmacokinetics. Technical limitations may also hamper advances in research on microbiota, and the expanded use of -omics techniques is expected to further improve the accuracy and efficiency of microbial investigations. More translational research that links clinical and in vitro/pre-clinical studies is warranted to facilitate microbiome-based personalized therapy.

#Gut microbiota #Drug pharmacokinetics #Drug metabolizing enzymes #Drug transporters

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