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The Gut-Brain Axis: The Missing Link in Depression
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논문 기본 정보

Type
Academic journal
Author
Journal
대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제13권 제3호 KCI Accredited Journals
Published
2015.1
Pages
239 - 244 (6page)

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The Gut-Brain Axis: The Missing Link in Depression
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Abstract· Keywords

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The gut microbiota is essential to human health and the immune system and plays a major role in the bidirectional communication between the gut and the brain. Based on evidence, the gut microbiota is associated with metabolic disorders such as obesity, diabetes mellitus and neuropsychiatric disorders such as schizophrenia, autistic disorders, anxiety disorders and major depressive disorders. In the past few years, neuroscientific research has shown the importance of the microbiota in the development of brain systems. Recent studies showed that the microbiota could activate the immune and central nervous systems, including commensal and pathogenic microorganisms in the gastrointestinal tract. Gut microorganisms are capable of producing and delivering neuroactive substances such as serotonin and gamma-aminobutyric acid, which act on the gut-brain axis. Preclinical research in rodents suggested that certain probiotics have antidepressant and anxiolytic activities. Effects may be mediated via the immune system or neuroendocrine systems. Herein, we present the latest literature examining the effects of the gut microbiota on depression.
#Depression #Probiotics #Microbiota.

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References (74)

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O'Mahony SM. / 2009 / Early life stress alters behavior, immunity, and microbiota in rats : implications for irritable bowel syndrome and psychiatric illnesses / Biol Psychiatry 65:263~267 google schola Round JL. / 2010 / Coordination of tolerogenic immune responses by the commensal microbiota / J Autoimmun 34:J220~J225 google schola Olszak T. / 2012 / Microbial exposure during early life has persistent effects on natural killer T cell function / Science 336:489~493 google schola Neish AS. / 2009 / Microbes in gastrointestinal health and disease / Gastroenterology 136:65~80 google schola Dinan TG. / 2011 / Probiotics in the treatment of depression : science or science fiction? / Aust N Z J Psychiatry 45:1023~1025 google schola

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