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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.6
- 수록면
- 60 - 61 (2page)
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초록· 키워드
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Commensalism in the gut has been suggested to influence many aspects of human health and disease. Emerging evidence suggests that the gut microbiota shapes systemic immunity, but the underlying mechanisms are poorly understood. The gut microbiota and its composition are important factors that determine responsiveness to immune checkpoint blockade in cancer. Here, by using gnotobiotic mice colonized with the human microbiota and antibiotics, we identified human microbes that promote tumor clearance upon PD-L1 blocking antibody treatment. Although high diversity in bacterial community has been correlated with responsiveness to PD-L1 blockade, we showed that colonization with a specific consortia of human gut bacteria or single microb^_@span style=color:#999999 ^_# ... ^_@/span^_#^_@a href=javascript:; onclick=onClickReadNode('NODE10593435');fn_statistics('Z354','null','null'); style='color:#999999;font-size:14px;text-decoration:underline;' ^_#전체 초록 보기^_@/a^_#
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UCI(KEPA) : I410-ECN-0101-2021-514-001919056