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Alterations in Gut Microbiota and Immunity by Dietary Fat
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Type
Academic journal
Author
Journal
Yonsei University College of Medicine Yonsei Medical Journal Yonsei Medical Journal 제58권 제6호 KCI Accredited Journals
Published
2017.1
Pages
1,083 - 1,091 (9page)

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Alterations in Gut Microbiota and Immunity by Dietary Fat
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Gut microbiota play critical physiological roles in energy extraction from the intestine and in the control of systemic immunity, as well as local intestinal immunity. Disturbance of gut microbiota leads to the development of several diseases, such as colitis, inflammatorybowel diseases, metabolic disorders, cancer, etc. From a metabolic point of view, the gut is a large metabolic organ and one of the first to come into contact with dietary fats. Interestingly, excessive dietary fat has been incriminated as a primary culpritof metabolic syndrome and obesity. After intake of high-fat diet or Western diet, extensive changes in gut microbiota have been observed, which may be an underlying cause of alterations in whole body metabolism and nutrient homeostasis. Here, we summarizerecent data on changes in the gut microbiota and immunity associated with dietary fat, as well as their relationships with the pathogenesis of metabolic syndrome. These findings may provide insight into the understanding of the complex pathophysiologyrelated to the development of metabolic diseases and offer an opportunity to develop novel candidates for therapeutic agents.
#Gut microbiota #gut immunity #obesity #diabetes

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References (25)

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Alenghat T / 2013 / Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis / Nature 504 : 153 ~ 157 google schola Arpaia N / 2013 / Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation / Nature 504 : 451 ~ 455 google schola Backhed F / 2004 / The gut microbiota as an environmental factor that regulates fat storage / Proc Natl Acad Sci U S A 101 : 15718 ~ 15723 google schola Backhed F / 2007 / Mechanisms underlying the resistance to diet-induced obesity in germfree mice / Proc Natl Acad Sci U S A 104 : 979 ~ 984 google schola Beltran-Sanchez H / 2013 / Prevalence and trends of metabolic syndrome in the adult U.S. population, 1999-2010 / J Am Coll Cardiol 62 : 697 ~ 703 google schola

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