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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.6
- 수록면
- 61 - 65 (5page)
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Clerodendrum trichotomum has been widely used as a traditional medicine for the treatment of numerous diseases, including pain management. However, there have been extremely limited pharmacological and phytochemical studies on Clerodendrum trichotomum up to now. In this study, we investigated the effects of the methanolic extract of Clerodendrum trichotomum (MCT) on nociceptive pain in mice. Our finding demonstrate that MCT treatment significantly extended the latency time in both the tail-immersion test and hot-plate test. Additionally, MCT treatment reduced acetic acid-induced writhing motions. These results suggest that MCT possesses strong anti-nociceptive activities against thermal and chemical nociception. In the formalin test, mice fed with MCT exhibited reduced licking time during both the early and late phases, thereby confirming the therapeutic potential of MCT in central and peripheral nociception. Furthermore, in combination tests using naloxone, the MCT-mediated anti-nociception was slightly reduced, indicating that MCT might act as a partial opioid receptor agonist. Based on these results, MCT may be a valuable candidate for the development of anti-nociceptive agents.
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Abstract
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참고문헌 (16)
참고문헌 신청
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Kim, H. J., Chung, W. C., Lee, K. M., Paik, C. N., Jung, S. H., Kim, J. D., Jung, S. H. and Kwak, J. W. (2009) Multiple gastrointestinal drug induced ulcers associated with aspirin and non-steroidal anti-inflammatory drugs: A case report and review of the literature. The Korean Journal of Gastrointestinal Endoscopy 39: 379-383.
Musumba, C., Pritchard, D. M. and Pirmohamed, M. (2009) Review article: cellular and molecular mechanisms of NSAIDinduced peptic ulcers. Alimentary Pharmacology and Therapeutics 30: 517-531. https://doi.org/10.1111/j.1365-2036.2009.04086.x
Soledad, M. C., Hernando, A., Olga, M. and Daniel, B. C. (2004) Addition of ultralow dose naloxone to postoperative morphine PCA : unchanged analgesia and opioid requirement but decreased incidence of opioid side effects. Pain 107: 41-46. https://doi.org/10.1016/j.pain.2003.09.011
Calixto, J. B, Beirith, A., Ferreira, J., Snatos, A. R., Filho, V. C. and Yunes, R. A. (2000) Naturally occurring antinociceptive substances from plants. Phyther. Res. 14: 401-418. https://doi.org/10.1002/1099-1573(200009)14:6<401::AID-PTR762>3.0.CO;2-H
Kim, H. J., Chung, W. C., Lee, K. M., Paik, C. N., Jung, S. H., Kim, J. D., Jung, S. H. and Kwak, J. W. (2009) Multiple gastrointestinal drug induced ulcers associated with aspirin and non-steroidal anti-inflammatory drugs: A case report and review of the literature. The Korean Journal of Gastrointestinal Endoscopy 39: 379-383.
Musumba, C., Pritchard, D. M. and Pirmohamed, M. (2009) Review article: cellular and molecular mechanisms of NSAIDinduced peptic ulcers. Alimentary Pharmacology and Therapeutics 30: 517-531. https://doi.org/10.1111/j.1365-2036.2009.04086.x
Soledad, M. C., Hernando, A., Olga, M. and Daniel, B. C. (2004) Addition of ultralow dose naloxone to postoperative morphine PCA : unchanged analgesia and opioid requirement but decreased incidence of opioid side effects. Pain 107: 41-46. https://doi.org/10.1016/j.pain.2003.09.011
Calixto, J. B, Beirith, A., Ferreira, J., Snatos, A. R., Filho, V. C. and Yunes, R. A. (2000) Naturally occurring antinociceptive substances from plants. Phyther. Res. 14: 401-418. https://doi.org/10.1002/1099-1573(200009)14:6<401::AID-PTR762>3.0.CO;2-H
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