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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제24권 제1호
- 발행연도
- 2020.1
- 수록면
- 19 - 26 (8page)
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초록· 키워드
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Medium- and long-chain triglyceride (MCT/LCT) propofol is widely used as an intravenous anesthetic, especially in the intensive care unit. The present study aimed to assess whether MCT/LCT propofol is safe in the hyperlipidemic population for long-term use. Free fatty acids (FFAs) were used to establish high-fat stimulation of HepG2 and Huh7 cells. Subsequently, these cells were treated with propofol at the concentration of 0, 4, or 8 μg/ml for 24 and 48 h. The results indicated that the cell viability was notably decreased when the cells were stimulated with 2 mmol/L FFAs and treated with 12 μg/ml MCT/LCT propofol. Accordingly, we chose 2 mmol/L FFAs along with 4 and 8 μg/ml MCT/LCT propofol for the subsequent experiments. Four and 8 μg/ml MCT/LCT propofol inhibited FFA-induced lipid accumulation in the cells and significantly reversed acetyl coenzyme A carboxylase (ACC) activity. In addition, MCT/LCT propofol not only significantly promoted the phosphorylation of AMPK and ACC, but also reversed the FFA-induced decreased phosphorylation of AMPK and ACC. In conclusion, MCT/LCT propofol reverses the negative effects caused by FFAs in HepG2 and Huh7 cells, indicating that MCT/LCT propofol might positively regulate lipid metabolism.
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등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Erickson SK / 2009 / Nonalcoholic fatty liver disease / J Lipid Res 50(Suppl):S412~S416
Day CP / 1998 / Steatohepatitis: a tale of two "hits"? / Gastroenterology 114:842~845
Singla B / 2018 / A prospective observational study of injection pain in children with medium plus long chain triglyceride and long chain triglyceride propofol premixed with lignocaine / Indian J Anaesth 62:214~218
Yew WS / 2005 / The effects of intravenous lidocaine on pain during injection of medium-and long-chain triglyceride propofol emulsions / Anesth Analg 100:1693~1695
Theilen HJ / 2002 / Propofol in a medium-and long-chain triglyceride emulsion : pharmacological characteristics and potential beneficial effects / Anesth Analg 95:923~929
Day CP / 1998 / Steatohepatitis: a tale of two "hits"? / Gastroenterology 114:842~845
Singla B / 2018 / A prospective observational study of injection pain in children with medium plus long chain triglyceride and long chain triglyceride propofol premixed with lignocaine / Indian J Anaesth 62:214~218
Yew WS / 2005 / The effects of intravenous lidocaine on pain during injection of medium-and long-chain triglyceride propofol emulsions / Anesth Analg 100:1693~1695
Theilen HJ / 2002 / Propofol in a medium-and long-chain triglyceride emulsion : pharmacological characteristics and potential beneficial effects / Anesth Analg 95:923~929
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