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논문 기본 정보

자료유형
학술저널
저자정보
김봉준 (고신대학교) 조경임 (고신대학교) 최지훈 (고신대학교병원) 박동현 (고신대학교) 유가인 (고신대학교) 임성일 (고신대학교) 김현수 (고신대학교) 허정호 (고신대학교) 차태준 (고신대학교)
저널정보
한국심초음파학회 Journal of Cardiovascular Imaging Journal of Cardiovascular Imaging 제24권 제4호
발행연도
2016.12
수록면
294 - 302 (9page)

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Background: In this study, we aimed to investigate the relationship between echocardiographic epicardial fat thickness (EFT),neutrophil to lymphocyte ratio (NLR; an important inflammatory marker), and diurnal blood pressure (BP) changes in patientswith recently diagnosed essential hypertension. Methods: A total of 647 patients underwent echocardiography and 24 hours of ambulatory BP monitoring. EFT was measuredby echocardiography, while NLR was measured by dividing the neutrophil count by the lymphocyte count. Patients were categorizedinto three groups according to BP pattern: the normotensive group, the dipper group, and the non-dipper group. Results: The mean EFT was highest in the non-dipper group (non-dipper group, 7.3 ± 3.0 mm; dipper group, 6.1 ± 2.0 mm;control group, 5.6 ± 2.0 mm; p < 0.001). NLR was also highest in the non-dipper group (non-dipper, 2.75 ± 2.81; dipper, 2.01 ±1.32; control, 1.92 ± 1.11; p < 0.001). EFT was significantly correlated with age (r = 0.160, p < 0.001) and NLR (r = 0.353, p <0.001). Furthermore, an EFT ≥ 7.0 mm was associated with the non-dipper BP pattern with 51.3% sensitivity and 71.6% specificity[95% confidence interval (CI) = 0.56?0.65, p < 0.001]. In a multivariate analysis, EFT [adjusted odds ratio (OR) = 3.99, 95%CI = 1.22?13.10, p = 0.022] and NLR (OR = 1.34, 95% CI = 1.05?1.71, p = 0.018) were independent parameters that distinguisheda non-dipper pattern after adjustment for cardiovascular risk factors. Conclusion: EFT and NLR are independently associated with impaired diurnal BP profiles in hypertensive individuals. EFT(as measured by echocardiography) and NLR appear to be helpful in stratifying cardiometabolic risk.

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