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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제20권 제6호
- 발행연도
- 2016.11
- 수록면
- 595 - 603 (9page)
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Ribosomal S6 kinase is a family of serine/threonine protein kinases involved in the regulation of cell viability. There are two subfamilies of ribosomal s6 kinase, (p90rsk, p70rsk). Especially, p90rsk is known to be an important downstream kinase of p44/42 MAPK. We investigated the role of p90rsk on ethanol-induced cell proliferation of HepG2 cells. HepG2 cells were treated with 10~50 mM of ethanol with or without ERK and p90rsk inhibitors. Cell viability was measured by MTT assay. The expression of pERK1, NHE1 was measured by Western blots. The phosphorylation of p90rsk was measured by ELISA kits. The expression of Bcl-2 was measured by qRT-PCR. When the cells were treated with 10~30 mM of ethanol for 24 hour, it showed significant increase in cell viability versus control group. Besides, 10~30 mM of ethanol induced increased expression of pERK1, p-p90rsk, NHE1 and Bcl-2. Moreover treatment of p90rsk inhibitor attenuated the ethanol-induced increase in cell viability and NHE1 and Bcl-2 expression. In summary, these results suggest that p90rsk, a downstream kinase of ERK, plays a stimulatory role on ethanol-induced hepatocellular carcinoma progression by activating anti-apoptotic factor Bcl-2 and NHE1 known to regulate cell survival.
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참고문헌 (44)
참고문헌 신청
Smith JA / 2005 / Identification of the first specific inhibitor of p90ribosomal S6 kinase(RSK)reveals an unexpected role for RSK in cancer cell proliferation / Cancer Res 65:1027~1034
Frödin M / 1999 / Role and regulation of 90 kDa ribosomal S6 kinase(RSK)in signal transduction / Mol Cell Endocrinol 151:65~77
Roux PP / 2003 / Phosphorylation of p90 ribosomal S6 kinase(RSK)regulates extracellular signal-regulated kinase docking and RSK activity / Mol Cell Biol 23:4796~4804
Zhang Y / 2001 / UVA induces Ser381 phosphorylation of p90RSK/MAPKAP-K1 via ERK and JNK pathways / J Biol Chem 276:14572~14580
Clark DE / 2005 / The serine/threonine protein kinase, p90 ribosomal S6 kinase, is an important regulator of prostate cancer cell proliferation / Cancer Res 65:3108~3116
Frödin M / 1999 / Role and regulation of 90 kDa ribosomal S6 kinase(RSK)in signal transduction / Mol Cell Endocrinol 151:65~77
Roux PP / 2003 / Phosphorylation of p90 ribosomal S6 kinase(RSK)regulates extracellular signal-regulated kinase docking and RSK activity / Mol Cell Biol 23:4796~4804
Zhang Y / 2001 / UVA induces Ser381 phosphorylation of p90RSK/MAPKAP-K1 via ERK and JNK pathways / J Biol Chem 276:14572~14580
Clark DE / 2005 / The serine/threonine protein kinase, p90 ribosomal S6 kinase, is an important regulator of prostate cancer cell proliferation / Cancer Res 65:3108~3116
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