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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제22권 제3호
- 발행연도
- 2018.5
- 수록면
- 269 - 275 (7page)
- DOI
- https://doi.org/10.4196/kjpp.2018.22.3.269
이용수
초록· 키워드
오류제보하기
Na+/H+ exchangers (NHEs) have been shown to be involved in regulating cell volume and maintaining fluid and electrolyte homeostasis. Pooled evidences have suggested that loss of Na+/H+ exchanger isoform 8 (NHE8) impairs intestinal mucosa. Whether NHE8 participates in the pathology of infectious colitis is still unknown.
Our previous study demonstrated that somatostatin (SST) could stimulate the expression of intestinal NHE8 so as to facilitate Na+ absorption under normal condition. This study further explored whether NHE8 participates in the pathological processes of infectious colitis and the effects of SST on intestinal NHE8 expression in the setting of infectious colitis. Our data showed that NHE8 expression was reduced in Citrobacter rodentium (CR) infected mice. Up-regulation of NHE8 improved diarrhea symptom and mucosal damage induced by CR. In vitro, a similar observation was also seen in Enteropathogenic E. coli (EPEC) infected Caco-2 cells. Seglitide, a SST receptor (SSTR) 2 agonist, partly reversed the inhibiting action of EPEC on NHE8 expression, but SSTR5 agonist (L-817,818) had no effect on the expression of NHE8.
Moreover, SST blocked the phosphorylation of p38 in EPEC-infected Caco-2 cells.
Taken together, these results suggest that enhancement of intestinal NHE8 expression by SST could ameliorate the symptoms of mice with infectious colitis.
목차
등록된 정보가 없습니다.
참고문헌 (37)
참고문헌 신청
Zachos NC / 2005 / Molecular physiology of intestinal $Na^{+}$ /$H^{+}$ exchange / Annu Rev Physiol 67:411~443
Fliegel L / 2005 / The $Na^{+}$ /$H^{+}$ exchanger isoform 1 / Int J Biochem Cell Biol 37:33~37
Schultheis PJ / 1998 / Renal and intestinal absorptive defects in mice lacking the NHE3 $Na^{+}$ /$H^{+}$ exchanger / Nat Genet 19:282~285
Aronson PS / 2002 / Ion exchangers mediating NaCl transport in the renal proximal tubule / Cell Biochem Biophys 36:147~153
Woo AL / 2003 / Renal function in NHE3-deficient mice with transgenic rescue of small intestinal absorptive defect / Am J Physiol Renal Physiol 284:F1190~F1198
Fliegel L / 2005 / The
Schultheis PJ / 1998 / Renal and intestinal absorptive defects in mice lacking the NHE3
Aronson PS / 2002 / Ion exchangers mediating NaCl transport in the renal proximal tubule / Cell Biochem Biophys 36:147~153
Woo AL / 2003 / Renal function in NHE3-deficient mice with transgenic rescue of small intestinal absorptive defect / Am J Physiol Renal Physiol 284:F1190~F1198
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