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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.9
- 수록면
- 680 - 686 (7page)
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Uncoupling proteins (UCPs) are mitochondrial inner membrane proteins that function to dissipate proton motive force and mitochondrial membrane potential. One UCP has been identified in Caenorhabditis elegans (C. elegans), namely UCP-4. In this study, we examined its expression and localization using a GFP marker in C. elegans. ucp-4 was expressed throughout the body from early embryo to aged adult and UCP-4 was localized in the mitochondria. It is known that increased mitochondrial membrane protential leads to a reactive oxygen species (ROS) increase, which is associated with age-related diseases, including neurodegenerative diseases in humans. A ucp-4 mutant showed increased mitochondrial membrane protential in association with increased neuronal defects during aging, and the neurons of ucp-4 overexpressing animals showed decreased neuronal defects during aging. These results suggest that UCP-4 may be involved in neuroprotection during aging via relieving mitochondrial membrane protential. We also investigated the relationship between UCP-4 and innate immunity because increased ROS can affect innate immunity. ucp-4 mutant displayed increased resistance to the pathogen Staphylococcus aureus com-pared to wild type. The enhanced immunity in the ucp-4 mutant could be related to increased mitochondrial membrane protential, presumably followed by increased ROS. In summary, UCP-4 might have an important role in neuronal aging and innate immune responses through mediating mitochondrial membrane protential.
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참고문헌 (52)
참고문헌 신청
Arsenijevic, D. / 2000 / Disruption of the uncoupling protein-2gene in mice reveals a role in immunity and reactive oxygen species production / Nat. Genet 26:435~439
Back, P. / 2012 / ROS in aging Caenorhabditis elegans : damage or signaling? / Oxid. Med. Cell Longev 2012:608478
Basu Ball, W. / 2011 / Uncoupling protein 2negatively regulates mitochondrial reactive oxygen species generation and induces phosphatase-mediated anti-inflammatory response in experimental visceral leishmaniasis / J. Immunol 187:1322~1332
Beckman, K. B. / 1998 / The free radical theory of aging matures / Physiol. Rev 78:547~581
Boveris, A. / 1972 / The cellular production of hydrogen peroxide / Biochem. J 128:617~630
Back, P. / 2012 / ROS in aging Caenorhabditis elegans : damage or signaling? / Oxid. Med. Cell Longev 2012:608478
Basu Ball, W. / 2011 / Uncoupling protein 2negatively regulates mitochondrial reactive oxygen species generation and induces phosphatase-mediated anti-inflammatory response in experimental visceral leishmaniasis / J. Immunol 187:1322~1332
Beckman, K. B. / 1998 / The free radical theory of aging matures / Physiol. Rev 78:547~581
Boveris, A. / 1972 / The cellular production of hydrogen peroxide / Biochem. J 128:617~630
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