지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.12
- 수록면
- 1,064 - 1,070 (7page)
이용수
초록· 키워드
오류제보하기
Translocator protein 18 kDa (TSPO) is a mitochondrial outer membrane protein and is abundantly expressed in a variety of organ and tissues. To date, the functional role of TSPO on vascular endothelial cell activation has yet to be fully elucidated. In the present study, the phorbol 12- myristate 13-acetate (PMA, 250 nM), an activator of protein kinase C (PKC), was used to induce vascular endothelial activation. Adenoviral TSPO overexpression (10-100 MOI) inhibited PMA-induced vascular cell adhesion molecule-1 (VCAM-1) and intracellular cell adhesion molecule-1 (ICAM-1) expression in a dose dependent manner. PMAinduced VCAM-1 expressions were inhibited by Mito- TEMPO (0.1-0.5 μM), a specific mitochondrial antioxidants, and cyclosporin A (1-5 μM), a mitochondrial permeability transition pore inhibitor, implying on an important role of mitochondrial reactive oxygen species (ROS) on the endothelial activation. Moreover, adenoviral TSPO overexpression inhibited mitochondrial ROS production and manganese superoxide dismutase expression. On contrasts, gene silencing of TSPO with siRNA increased PMAinduced VCAM-1 expression and mitochondrial ROS production.
Midazolam (1-50 μM), TSPO ligands, inhibited PMA-induced VCAM-1 and mitochondrial ROS production in endothelial cells. These results suggest that mitochondrial TSPO can inhibit PMA-induced endothelial inflammation via suppression of VCAM-1 and mitochondrial ROS production in endothelial cells.
목차
등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Anholt, R. R. / 1986 / The peripheral-type benzodiazepine receptor. Localization to the mitochondrial outer membrane / J. Biol. Chem 261:576~583
배윤수 / 2011 / Regulation of Reactive Oxygen Species Generation in Cell Signaling / Molecules and Cells 32(6):491~509
Basso, E. / 2005 / Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D / J. Biol. Chem 280:18558~18561
Bono, F. / 1999 / Peripheral benzodiazepine receptor agonists exhibit potent antiapoptotic activities / Biochem. Biophys. Res. Commun 265:457~461
Chen, K. H. / 1999 / Mitochondrial glutathione modulates TNF-alpha-induced endothelial cell dysfunction / Free Radic. Biol. Med 27:100~109
배윤수 / 2011 / Regulation of Reactive Oxygen Species Generation in Cell Signaling / Molecules and Cells 32(6):491~509
Basso, E. / 2005 / Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D / J. Biol. Chem 280:18558~18561
Bono, F. / 1999 / Peripheral benzodiazepine receptor agonists exhibit potent antiapoptotic activities / Biochem. Biophys. Res. Commun 265:457~461
Chen, K. H. / 1999 / Mitochondrial glutathione modulates TNF-alpha-induced endothelial cell dysfunction / Free Radic. Biol. Med 27:100~109
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
RIP3-Dependent Accumulation of Mitochondrial Superoxide Anions in TNF-α-Induced Necroptosis
Molecules and Cells
2022 .04
-
Optimization of mitochondrial isolation method for cancer cell metabolism study
한국분석과학회 학술대회
2022 .05
-
Essential Function of Aco2, a Fusion Protein of Aconitase and Mitochondrial Ribosomal Protein BL21, in Mitochondrial Translation in Fission Yeast
한국미생물학회 학술대회논문집
2015 .04
-
Simple endothelial cell patterning induced by reactive oxygen species on PDMS
한국진공학회 학술발표회초록집
2016 .08
-
Emerging Role of Mitochondrial Dynamics in Viral Infection
한국미생물학회 학술대회논문집
2017 .04
-
Genetic mutations affecting mitochondrial function in cancer drug resistance
Genes & Genomics
2023 .03
-
Insertion and Dislocation of Membrane Proteins in the Mitochondrial Inner Membrane
한국미생물학회 학술대회논문집
2015 .04
-
Peroxiredoxin 3 Has Important Roles on Arsenic Trioxide Induced Apoptosis in Human Acute Promyelocytic Leukemia Cell Line via Hyperoxidation of Mitochondrial Specific Reactive Oxygen Species
Molecules and Cells
2020 .01
-
1-Methoxylespeflorin G11 Protects HT22 Cells from Glutamate-Induced Cell Death through Inhibition of ROS Production and Apoptosis
Journal of Microbiology and Biotechnology
2021 .01
-
A Molecular Approach to Mitophagy and Mitochondrial Dynamics
Molecules and Cells
2018 .01
-
Inhibition of Jurkat T Cell Proliferation by Active Components of Rumex japonicus Roots Via Induced Mitochondrial Damage and Apoptosis Promotion
Journal of Microbiology and Biotechnology
2020 .01
-
Mitochondrial Efficiency-Dependent Viability of Saccharomyces cerevisiae Mutants Carrying Individual Electron Transport Chain Component Deletions
Molecules and Cells
2015 .12
-
Picropodophyllotoxin Induces G1 Cell Cycle Arrest and Apoptosis in Human Colorectal Cancer Cells via ROS Generation and Activation of p38 MAPK Signaling Pathway
Journal of Microbiology and Biotechnology
2021 .12
-
Augmenter of Liver Regeneration Alleviates Renal Hypoxia-Reoxygenation Injury by Regulating Mitochondrial Dynamics in Renal Tubular Epithelial Cells
Molecules and Cells
2019 .01
-
Protective Effect of Fucoidan Extract from Ecklonia cava on Hydrogen Peroxide-Induced Neurotoxicity
Journal of Microbiology and Biotechnology
2018 .01
-
Suboptimal Mitochondrial Activity Facilitates Nuclear Heat Shock Responses for Proteostasis and Genome Stability
Molecules and Cells
2023 .06
-
Uncoupling Protein, UCP-4 May Be Involved in Neuronal Defects During Aging and Resistance to Pathogens in Caenorhabditis elegans
Molecules and Cells
2016 .09
-
The Mitochondrial Fusion-Related Proteins Mfn2 and OPA1 are Transcriptionally Induced during Differentiation of Bone Marrow Progenitors to Immature Dendritic Cells
Molecules and Cells
2015 .01
-
A20 ameliorates disc degeneration by suppressing mTOR/BNIP3 axis-mediated mitophagy
Genes & Genomics
2023 .05
-
Alleviation of Senescence via ATM Inhibition in Accelerated Aging Models
Molecules and Cells
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0