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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.8
- 수록면
- 603 - 610 (8page)
- DOI
- molcells.2016.0072
이용수
초록· 키워드
오류제보하기
Recently, an increasing number of studies have focused on the effects of CD4+ T cell on cognitive function. How-ever, the changes of Th2 cytokines in restricted CD4+ T cell receptor (TCR) repertoire model and their effects on the adult hippocampal neurogenesis and memory are not fully understood. Here, we investigated whether and how the mice with restricted CD4+ repertoire TCR exhibit learning and memory impairment by using OT-II mice. OT-II mice showed decreased adult neurogenesis in hippocampus and short- and long- term memory impairment. Moreover, Th2 cytokines in OT-II mice are significantly increased in peripheral organs and IL-4 is significantly increased in brain. Finally, IL-4 treatment significantly inhibited the proliferation of cultured adult rat hippocampal neural stem cells. Taken together, abnormal level of Th2 cytokines can lead memory dysfunction via impaired adult neurogenesis in OT-II transgenic.
목차
등록된 정보가 없습니다.
참고문헌 (64)
참고문헌 신청
Ainge, J. A. / 2007 / Hippocampal CA1 place cells encode intended destination on a maze with multiple choice points / J. Neurosci 27:9769~9779
Antunes, M. / 2012 / The novel object recognition memory : neurobiology, test procedure, and its modifications / Cogn. Process 13:93~110
Arai, Y. / 2011 / Neural stem and progenitor cells shorten S-phase on commitment to neuron production / Nat. Commun 2:154
Banchereau, J. / 1998 / Dendritic cells and the control of immunity / Nature 392:245~252
Bannerman, D. M. / 2014 / Hippocampal synaptic plasticity, spatial memory and anxiety / Nat. Rev. Neurosci 15:181~192
Antunes, M. / 2012 / The novel object recognition memory : neurobiology, test procedure, and its modifications / Cogn. Process 13:93~110
Arai, Y. / 2011 / Neural stem and progenitor cells shorten S-phase on commitment to neuron production / Nat. Commun 2:154
Banchereau, J. / 1998 / Dendritic cells and the control of immunity / Nature 392:245~252
Bannerman, D. M. / 2014 / Hippocampal synaptic plasticity, spatial memory and anxiety / Nat. Rev. Neurosci 15:181~192
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