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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제12호
- 발행연도
- 2017.1
- 수록면
- 2,237 - 2,240 (4page)
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초록· 키워드
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In the present study, we investigated the effect of tyndallized HY7712 (tHY7712) on the expression of Th cell specific transcription factors and cytokines in whole-body γ-irradiated mice. Oral administration of tHY7712 strongly recovered the γ-irradiation-suppressed expression of helper T (Th) cell- and regulatory T cell-related transcription factors and cytokines, such as T-bet, Foxp3, IFN-γ, TNF-α, and IL-10, and suppressed Th2 cell-associated transcription factor and cytokine GATA3 and IL-5, respectively. Furthermore, compared with the control, tHY7712 treatment also restored γ-irradiation-impaired natural killer and cytotoxic T cell activities against YAC-1 tumor cells to 97.8% and 98.6%, respectively.
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등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Alok A / 2017 / Probiotics: a new era of biotherapy / Adv. Biomed. Res 6 : 31 ~
Chapoval S / 2010 / Regulation of the T helper cell type 2 (Th2)/T regulatory cell (Treg) balance by IL-4 and STAT6 / J. Leukoc. Biol 87 : 1011 ~ 1018
Chen R / 2016 / Impairment of the intrinsic capability of Th1 polarization in irradiated mice: a close look at the imbalanced Th1/Th2 response after irradiation / Radiat. Res
Ghazy AA / 2015 / Effect of murine exposure to gamma rays on the interplay between Th1 and Th2 lymphocytes / Front. Pharmacol 6 : 74 ~
Hamad A / 2013 / A systematic review and meta-analysis of probiotics for the management of radiation induced bowel disease / Clin. Nutr 32 : 353 ~ 360
Chapoval S / 2010 / Regulation of the T helper cell type 2 (Th2)/T regulatory cell (Treg) balance by IL-4 and STAT6 / J. Leukoc. Biol 87 : 1011 ~ 1018
Chen R / 2016 / Impairment of the intrinsic capability of Th1 polarization in irradiated mice: a close look at the imbalanced Th1/Th2 response after irradiation / Radiat. Res
Ghazy AA / 2015 / Effect of murine exposure to gamma rays on the interplay between Th1 and Th2 lymphocytes / Front. Pharmacol 6 : 74 ~
Hamad A / 2013 / A systematic review and meta-analysis of probiotics for the management of radiation induced bowel disease / Clin. Nutr 32 : 353 ~ 360
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