지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.3
- 수록면
- 1 - 8 (8page)
이용수
이 논문의 연구 히스토리 (2)
- 이 논문의 후속연구가 궁금하신가요?
- 연관 학술논문 또는 학술발표를 통해 보다 발전된 연구결과를 확인하실 수 있습니다.
- 이 논문의 연구 히스토리 확인하기
초록· 키워드
오류제보하기
The skin is an important barrier that protects the body from harmful environments such as UV rays. When the skin is repeatedly stimulated, such as UV rays, ROS and pro-inflammatory cytokines are overproduced. As a result, the proteins and nucleic acids that make up the skin are damaged, and aging occurs. Esculetin is known to have anti-inflammatory, antioxidant and UV-induced MMP-1 inhibitory effects. However, the inhibitory effect of MMP-1 on TNF-α-induced fibroblasts is not known. Therefore, in this study, the MMP-1 inhibitory effect of esculetin was confirmed in TNF-α-induced fibroblasts. As a result of confirming the cytotoxicity of esculetin in Hs68 cells by MTT assay, there was no significant toxicity up to 200 μM. As a result of real-time PCR and ELISA, it was confirmed that esculetin inhibited the expression of MMP-1. Esculetin did not inhibit MAPK (ERK, JNK, p38) phosphorylation, but inhibited phosphorylation of the mTOR-p70S6k signaling pathway. In addition, it was confirmed that the phosphorylation of the transcription factor NF-κB was inhibited. These results suggest that esculetin has potential as an anti-aging material.
목차
Abstract
재료 및 방법
결과 및 고찰
결론
인용문헌
참고문헌 (33)
참고문헌 신청
Puizina-Ivic, N. (2008) Skin Aging. Acta Dermatoven APA 17: 47-54.
정진호 (2001) 한국인의 피부노화 특징 및 발생기전. J. Soc. Cosmet. 27: 31-35.
Uitto, J. (1997) Understanding, premature skin aging, N. Engl. J. Med. 337: 1463-1465. https://doi.org/10.1056/NEJM199711133372011
Quan, T. and Fisher, G. J. (2015) Role of age-associated alterations of the dermal extracellular matrix microenvironment in human skin aging: a mini-review. Gerontology 61: 427-434. https://doi.org/10.1159/000371708
Quan, T., Qin, Z., Xia, W. and Shao, Y. (2009) Matrix-degrading metalloproteinases in photoaging. J. Investig. Dermatol. Symp. Proc. 14: 20-24. https://doi.org/10.1038/jidsymp.2009.8
정진호 (2001) 한국인의 피부노화 특징 및 발생기전. J. Soc. Cosmet. 27: 31-35.
Uitto, J. (1997) Understanding, premature skin aging, N. Engl. J. Med. 337: 1463-1465. https://doi.org/10.1056/NEJM199711133372011
Quan, T. and Fisher, G. J. (2015) Role of age-associated alterations of the dermal extracellular matrix microenvironment in human skin aging: a mini-review. Gerontology 61: 427-434. https://doi.org/10.1159/000371708
Quan, T., Qin, Z., Xia, W. and Shao, Y. (2009) Matrix-degrading metalloproteinases in photoaging. J. Investig. Dermatol. Symp. Proc. 14: 20-24. https://doi.org/10.1038/jidsymp.2009.8
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
A431 skin cancer cell에서 Esculetin의 MAPKs pathway를 통한 항암 효과
생약학회지(Korean Journal of Pharmacognosy)
2022 .12
-
Esculetin Inhibits the Survival of Human Prostate Cancer Cells by Inducing Apoptosis and Arresting the Cell Cycle
대한암예방학회지
2018 .01
-
Esculetin Prevents the Induction of Matrix Metalloproteinase-1 by Hydrogen Peroxide in Skin Keratinocytes
대한암예방학회지
2019 .01
-
Esculetin이 PI3K/MAPK 경로 하향 조절을 통해 collagen 유도의 혈소판 응집 억제에 미치는 효과
생약학회지(Korean Journal of Pharmacognosy)
2021 .09
-
Esculetin, a Coumarin Derivative, Exhibits Anti-proliferative and Pro-apoptotic Activity in G361 Human Malignant Melanoma
대한암예방학회지
2015 .01
-
Esculetin을 담지한 ZnO microsphere 외용제의 광노화 차단 상가 효능
동의생리병리학회지
2019 .01
-
Esculetin attenuates neurotoxicity induced by zinc oxide nanoparticles in Sprague Dawley rats
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Esculetin, a Coumarin Derivative, Inhibits Aldose Reductase Activity in vitro and Cataractogenesis in Galactose-Fed Rats
Biomolecules & Therapeutics(구 응용약물학회지)
2016 .01
-
Esculetin attenuates receptor activator of nuclear factor kappa-B ligand-mediated osteoclast differentiation through c-Fos/nuclear factor of activated T-cells c1 signaling pathway
대한체질인류학회 학술대회 연제 초록
2015 .05
-
Serum Levels of MMP9 and MMP2 in Patients with Oral Squamous Cell Carcinoma
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Serum Level of Matrix Metalloproteinase-2 and -9 in Patients with Laryngeal Squamous Cell Carcinoma and Clinical Significance
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Characteristics of Expression of Matrix Metalloproteinases (MMP-2 and MMP-9) in Glottic Squamous Cell Carcinoma and Benign Vocal Fold Lesions
Clinical and Experimental Otorhinolaryngology
2015 .01
-
Rhus Verniciflua Stokes Extract Suppresses Expression of Metalloproteinases, iNOS and COX-2 in THP-1 Cells Via Inhibiting NF-κB and MAPK Phosphorylation
대한한의학회지
2020 .12
-
사람 피부 섬유아세포에서 자외선으로 유도된 기질분해효소-1과 기질분해효소-3의 발현 유도에 대한 사상자 추출물의 억제효과
동의생리병리학회지
2019 .06
-
Inhibition of matrix metalloproteinases: a troubleshooting for dentin adhesion
Restorative Dentistry and Endodontics
2020 .01
-
사람 피부 섬유아세포에서 자외선으로 유도된 기질분해효소-1과 기질분해효소-3의 발현 유도에 대한 사상자 추출물의 억제효과
동의생리병리학회지
2019 .01
-
Inhibition of the Expression of Matrix Metalloproteinases in Articular Chondrocytes by Resveratrol through Affecting Nuclear Factor-Kappa B Signaling Pathway
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
Antioxidant and Skin Anti-Aging Effects of Marigold Methanol Extract
Toxicological Research
2018 .01
-
Pleiotropic Roles of Metalloproteinases in Hematological Malignancies: an Update
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Tetrabromobisphenol A Induces MMP-9 Expression via NADPH Oxidase and the activation of ROS, MAPK, and Akt Pathways in Human Breast Cancer MCF-7 Cells
Toxicological Research
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0