Esculetin, a Coumarin Derivative, Inhibits Aldose Reductase Activity in vitro and Cataractogenesis in Galactose-Fed Rats

Kim, Chan-Sik; Kim, Junghyun; Lee, Yun Mi; Sohn, Eunjin; Kim, Jin Sook

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자료유형: 학술저널

저자정보: Kim, Chan-Sik (Korean Medicine Convergence Research Division, Korea Institute of Oriental Medicine) Kim, Junghyun (Korean Medicine Convergence Research Division, Korea Institute of Oriental Medicine) Lee, Yun Mi (Korean Medicine Convergence Research Division, Korea Institute of Oriental Medicine) Sohn, Eunjin (Korean Medicine Convergence Research Division, Korea Institute of Oriental Medicine) Kim, Jin Sook (Korean Medicine Convergence Research Division, Korea Institute of Oriental Medicine)

저널정보: 한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제24권 제2호

발행연도: 2016.1

수록면: 178 - 183 (6page)

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연구배경

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🏆

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Naturally occurring coumarin compounds have received substantial attention due to their pharmaceutical effects. Esculetin is a coumarin derivative and a polyphenol compound that is used in a variety of therapeutic and pharmacological strategies. However, its effect on aldose reductase activity remains poorly understood. In this study, the potential beneficial effects of esculetin on lenticular aldose reductase were investigated in galactose-fed (GAL) rats, an animal model of sugar cataracts. Cataracts were induced in Sprague-Dawley (SD) rats via a 50% galactose diet for 2 weeks, and groups of GAL rats were orally treated with esculetin (10 or 50 mg/kg body weight). In vehicle-treated GAL rats, lens opacification was observed, and swelling and membrane rupture of the lens fiber cells were increased. Additionally, aldose reductase was highly expressed in the lens epithelium and superficial cortical fibers during cataract development in the GAL rats. Esculetin reduced rat lens aldose reductase (RLAR) activity in vitro, and esculetin treatment significantly inhibited lens opacity, as well as morphological alterations, such as swelling, vacuolation and liquefaction of lens fibers, via the inhibition of aldose reductase in the GAL rats. These results indicate that esculetin is a useful treatment for galactose-induced cataracts.

#Aldose reductase #Esculetin #Sugar cataract #Galactose #Lens fibers

참고문헌 (31)

참고문헌 신청

Brubaker, A. N / 1986 / Synthesis and rat lens aldose reductase inhibitory activity of some benzopyran-2-ones / J. Med. Chem 29:1094~1099

Crabbe, M. J / 1998 / Aldose reductase: a window to the treatment of diabetic complications? / Prog. Retin. Eye. Res 17:313~383

de la Fuente, J. A / 2003 / Aldose reductase inhibitors from natural sources / Nat. Prod. Rep 20:243~251

Dvornik, E / 1973 / Polyol accumulation in galactosemic and diabetic rats: control by an al dose reductase inhibitor / Science 182:1146~1148

Egan, D / 1990 / The pharmacology, metabolism, analysis, and applications of coumarin and coumarin-related compounds / Drug. Metab. Rev 22:503~529

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