Serum Levels of MMP9 and MMP2 in Patients with Oral Squamous Cell Carcinoma

Lotfi, Alireza; Mohammadi, Ghodrat; Tavassoli, Atena; mousaviagdas, Mehrnoosh; Chavoshi, Hadi; Saniee, Lale

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자료유형: 학술저널

저자정보: Lotfi, Alireza (Department of Otorhinolaryngology, Tabriz University of Medical Sciences) Mohammadi, Ghodrat (Department of Otorhinolaryngology, Tabriz University of Medical Sciences) Tavassoli, Atena (Hematology and Oncology Research Center, Tabriz University of Medical Sciences) mousaviagdas, Mehrnoosh (Department of Otorhinolaryngology, Tabriz University of Medical Sciences) Chavoshi, Hadi (Hematology and Oncology Research Center, Tabriz University of Medical Sciences) Saniee, Lale (Hematology and Oncology Research Center, Tabriz University of Medical Sciences)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제4호

발행연도: 2015.1

수록면: 1,327 - 1,330 (4page)

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Background: Squamous cell carcinoma (SCC) is the most common cancer in the oral area. Matrix metalloproteinases (MMPs) and especially MMP-2 and MMP-9 are increased in malignancy and lymph node involvement in oral SCCs. We aimed to evaluate the serum levels of MMP-2 and MMP-9 in patients with oral SCC compared to normal subjects and their relation with clinicopathological findings. Materials and Methods: In this case control study, 20 patients with oral SCC and 20 healthy subjects were included and serum levels of MMP-2 and MMP-9 were compared between groups. Also, the correlation between these markers with clinicopathological findings including grade (T) and node (N) were evaluated. Results: Patients with oral SCC had significantly higher serum levels of MMP-2 (p=0.01) and MMP-9 (p<0.001) compared to healthy subjects. With increase in grade T, MMP-2 was significantly increased (p=0.001), but in the MMP-9 case this was not significant (p=0.27). The levels of MMP-2 (p=0.002) and MMP-9 (p=0.01) in cases with lymph node involvement and that of MMP-2 in subjects with smoking history (p=0.001) were significantly high. There was significantly positive correlation between MMP-2 with grade T tumor (r=0.598, p=0.005), lymph node involvement (r=0.737, p<0.001) and smoking (r=0.674, p=0.001) and also between MMP-9 and lymph node involvement (r=0.474, p=0.03). Conclusions: Both markers are significantly increased in oral SCC compared to healthy subjects. However, MMP-2 was better for evaluating lymph node involvement and tumor grade.

#Squamous cell carcinoma #matrix metalloproteinase 2 #matrix metalloproteinase 9 #grade

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