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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.12
- 수록면
- 181 - 191 (11page)
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As the incidence of skin cancer increases every year, non-surgical treatment methods for cancer are being sought. Esculetin, a natural dihydroxy coumarin, is attracting attention as a therapeutic agent for certain diseases, such as cancer, based on its broad pharmacological activity. In this study, the anticancer ability of esculetin was evaluated using the epidermoid carcinoma cell line A431. As a result of evaluating the apoptosis ability of esculetin by MTT assay, apoptosis was observed in a time-concentration-dependent manner regardless of the presence or absence of FBS. As a result of quantitative real-time PCR, esculetin reduced cyclin D1 mRNA in a time-concentration-dependent manner. In addition, as a result of western blotting, esculetin significantly inhibited phosphorylation of ERK, JNK, and p38 in a concentration-dependent manner. The results of this study suggest that esculetin has the potential to be used as an effective natural medicine for the treatment of skin cancer.
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Abstract
재료 및 방법
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참고문헌 (21)
참고문헌 신청
Park, J. E., Kim, D. H., Ha, E. Y., Choi, S. M., Choi, J. S., Chun, K. S. and Joo, S. H. (2019) Thymoquinone induces apoptosis of human epidermoid carcinoma A431 cells through ROS-mediated suppression of STAT3. Chem. Biol. Interact. 312: 108799.
Amini, S., Viera, M. H., Valins, W. and Berman, B. (2010) Nonsurgical innovations in the treatment of nonmelanomaskin cancer. J. Clin. Aesthet. Dermatol. 3: 20-34.
Madan, V., Lear, J. T. and Szeimies, R. M. (2010) Non-melanoma skin cancer. Lancet. 375: 673-685.
Kohno, M. and Pouyssegur, J. (2006) Targeting the ERK signaling pathway in cancer therapy. Annals of Medicine 38: 200-211.
Yuan, J., Dong, X., Yap, J. and Hu, J. (2020) The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy. J. Hematol. Oncol. 13: 1-19.
Amini, S., Viera, M. H., Valins, W. and Berman, B. (2010) Nonsurgical innovations in the treatment of nonmelanomaskin cancer. J. Clin. Aesthet. Dermatol. 3: 20-34.
Madan, V., Lear, J. T. and Szeimies, R. M. (2010) Non-melanoma skin cancer. Lancet. 375: 673-685.
Kohno, M. and Pouyssegur, J. (2006) Targeting the ERK signaling pathway in cancer therapy. Annals of Medicine 38: 200-211.
Yuan, J., Dong, X., Yap, J. and Hu, J. (2020) The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy. J. Hematol. Oncol. 13: 1-19.
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