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논문 기본 정보

자료유형
학술저널
저자정보
Tahereh Zadeh Mehrizi (Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicin) Sedigheh Amini Kafiabad (Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicin) Peyman Eshghi (Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical S)
저널정보
대한혈액학회 Blood Research Blood Research Vol.56 No.4
발행연도
2021.12
수록면
215 - 228 (14page)
DOI
10.5045/br.2021.2021094

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Maintaining the quality of platelet products and increasing their storage time are priorities for treatment applications. The formation of platelet storage lesions that limit the storage period and preservation temperature, which can prepare a decent environment for bacterial growth, are the most important challenges that researchers are dealing with in platelet preservation. Nanotechnology is an emerging field of science that has introduced novel solutions to resolve these problems. Here, we reviewed the reported effects of polymeric nanoparticles?including chitosan, dendrimers, polyethylene glycol (PEG), and liposome? on platelets in articles from 2010 to 2020. As a result, we concluded that the presence of dendrimer nanoparticles with a smaller size, negative charge, low molecular weight, and low concentration along with PEGylation can increase the stability and survival of platelets during storage. In addition, PEGylation of platelets can also be a promising approach to improve the quality of platelet bags during storage.

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