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Anti-platelet Effects of Isoscopoletin through Regulation of PI3K/Akt and MAPK on Collagen-induced Human Platelets
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콜라겐-유도의 사람 혈소판에서 PI3K/Akt 및 MAPK 조절을 통한 Isoscopoletin의 항혈소판 효과

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Type
Academic journal
Author
Dong-Ha Lee (남서울대학교)
Journal
Korean Society of Phamacognosy 생약학회지(Korean Journal of Pharmacognosy) Vol.51 No.3 KCI Accredited Journals SCOPUS
Published
2020.9
Pages
151 - 157 (7page)

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Anti-platelet Effects of Isoscopoletin through Regulation of PI3K/Akt and MAPK on Collagen-induced Human Platelets
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When blood vessels are damaged, a rapid hemostatic reaction occurs to minimize blood loss and maintain normal circulation. Platelet activation and aggregation is essential in this process. However, excessive platelet aggregation or abnormal platelet aggregation may be the cause of cardiovascular disease, such as thrombosis, stroke and atherosclerosis. Therefore, it is important to prevent and treat cardiovascular disease by finding substances that can regulate platelet activation and suppress aggregation reactions. Isoscopoletin, which is mainly found in the roots of plants Artemisia or Scopolia, has been reported to have potential pharmacological effects on anticancer and Alzheimer’s disease, but its role and mechanisms for platelet aggregation and thrombus formation are unknown. This study confirmed the effect of isoscopoletin on major regulation of collagen-induced human platelet aggregation, TXA₂ production and intracellular granular secretion (ATP and serotonin release). In addition, the effects of isoscopoletin on phosphorylation of phosphorylated proteins PI3K/Akt and MAPK involved in signal transduction in platelet aggregation was studied. As a result, isoscopoletin significantly inhibited the phosphorylation of PI3K/Akt and MAPK, significantly inhibiting platelet aggregation through TXA₂ production and intracellular granular secretion (ATP and serotonin release). Therefore, we suggest that isoscopoletin is an anti-platelet substance that regulates phosphorylation of phosphorus proteins such as PI3K/Akt and MAPK and is valuable as a preventive and therapeutic agent for platelet-derived cardiovascular disease.
#Isoscopoletin #PI3K/Akt #MAPK #TXA₂ #Granule secretion

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References (29)

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Jackson, S. P. / 2011 / Arterial thrombosis?insidious, unpredictable and deadly / Nat. Med 17:1423~1436 google schola Schwartz, S. M. / 1990 / Developmental mechanisms underlying pathology of arteries / Physiol. Rev 70:1177~1209 google schola Payrastre, B. / 2000 / The integrin alpha IIb/beta 3 in human platelet signal transduction / Biochem. Pharmacol 60:1069~1074 google schola Morello, F. / 2009 / Phosphoinositide 3-kinase signalling in the vascular system / Cardiovasc. Res 82:261~271 google schola Jennings, L. K. / 2009 / Role of platelets in atherothrombosis / Am. J. Cardiol 103:4A~10A google schola

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