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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.6
- 수록면
- 64 - 69 (6page)
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초록· 키워드
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When blood vessels are damaged, a rapid hemostatic response should occur in order to lower blood loss and keep normal circulation, and platelet activation and aggregation are essential. Nevertheless, abnormal or excessive platelet aggregation can be a reason of cardiovascular diseases including thrombosis, atherosclerosis, and stroke. Therefore, the screening for a substance which can regulate platelet activation and suppress aggregation reaction is very important for treatment and prevention of cardiovascular diseases. Artemether is a methyl ether derivative of artemisinin, which is isolated from the antimalarial plant Artemisia annua, but research on platelet aggregation or its mechanisms is still insufficient. This study identified the effects of artemether on U46619-induced human platelet aggregation and their granule secretion (ATP and serotonin release). In addition, the effects of artemether on the phosphorylation of PI3K/Akt or MAPK, which are related to signal transduction in platelet aggregation, were studied. As the results, artemether significantly lowered PI3K/Akt and MAPK phosphorylation, which inhibited platelet aggregation through granule secretion (ATP and serotonin release) dose-dependently. Therefore, we suggest that artemether is an antiplatelet substance that regulates PI3K/Akt and MAPK pathway and is of value as a therapeutic and preventive agent for platelet-derived cardiovascular diseases.
목차
Abstract
재료 및 방법
결과 및 고찰
결론
인용문헌
참고문헌 (21)
참고문헌 신청
Jackson, S. P. (2011) Arterial thrombosis?insidious, unpredictable and deadly. Nat. Med. 17: 1423-1436.
Schwartz, S. M., Heimark, R. L. and Majesky, M. W. (1990) Developmental mechanisms underlying pathology of arteries. Physiol. Rev. 70: 1177-1209.
Payrastre, B., Missy, K., Trumel, C., Bodin, S., Plantavid, M. and Chap, H. (2000) The integrin alpha IIb/beta 3 in human platelet signal transduction. Biochem. Pharmacol. 60: 1069-1074.
Phillips, D. R., Nannizzi-Alaimo, L. and Prasad, K. S. (2001) Beta3 tyrosine phosphorylation in alphaIIbbeta3 (platelet membrane GP IIb-IIIa) outside-in integrin signaling. Thromb. Haemost. 86: 246-258.
Morello, F., Perino, A. and Hirsch, E. (2009) Phosphoinositide 3-kinase esculetin in the vascular system. Cardiovasc. Res. 82: 261-271.
Schwartz, S. M., Heimark, R. L. and Majesky, M. W. (1990) Developmental mechanisms underlying pathology of arteries. Physiol. Rev. 70: 1177-1209.
Payrastre, B., Missy, K., Trumel, C., Bodin, S., Plantavid, M. and Chap, H. (2000) The integrin alpha IIb/beta 3 in human platelet signal transduction. Biochem. Pharmacol. 60: 1069-1074.
Phillips, D. R., Nannizzi-Alaimo, L. and Prasad, K. S. (2001) Beta3 tyrosine phosphorylation in alphaIIbbeta3 (platelet membrane GP IIb-IIIa) outside-in integrin signaling. Thromb. Haemost. 86: 246-258.
Morello, F., Perino, A. and Hirsch, E. (2009) Phosphoinositide 3-kinase esculetin in the vascular system. Cardiovasc. Res. 82: 261-271.
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