지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 262 - 267 (6page)
- DOI
- 10.4285/kjt.21.0017
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초록· 키워드
오류제보하기
Atypical hemolytic uremic syndrome (aHUS) is a rare disease caused by complement dysregulation that may involve the extra-renal system. Without appropriate prophylactic treatment, aHUS commonly recur after kidney transplantation (KT). In contrast, cytomegalovirus (CMV) infection is common in KT recipients and may affect various organ systems. Herein, we report a case of recurrent aHUS complicated by CMV enteritis. This 17-year-old KT recipient with aHUS having a CFH mutation was admitted to the hospital for gastric pain and vomiting. With worsening hemogram, recurrence of aHUS involving the gastrointestinal (GI) system was suspected. Upon treatment with anti-C5 antibody, the patient’s blood counts soon improved, but her GI symptoms did not. Esophagogastroduodenoscopy revealed multiple ulcers in the duodenum with pathologic findings consistent with aHUS and CMV enteritis; however, she did not have CMV antigenemia despite these findings. Treatment with ganciclovir resolved GI symptoms within 7 days.
This case shows that recurrence of aHUS is often induced by intercurrent infection, and common infections after allograft transplantation, such as CMV, should always be suspected and confirmed for a proper treatment, particularly because CMV enteritis may not accompany CMV antigenemia.
목차
등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Nester CM / 2015 / Atypical aHUS : state of the art / Mol Immunol 67:31~42
Hofer J / 2014 / Extra-renal manifestations of complement-mediated thrombotic microangiopathies / Front Pediatr 2:97
Ito S / 2019 / Safety and effectiveness of eculizumab for pediatric patients with atypical hemolytic-uremic syndrome in Japan : interim analysis of post-marketing surveillance / Clin Exp Nephrol 23:112~121
Poornima Ramanan / 2013 / Cytomegalovirus Infections in Solid Organ Transplantation: A Review / Infection and Chemotherapy 45(3):260~271
Olie KH / 2005 / Posttransplantation cytomegalovirus-induced recurrence of atypical hemolytic uremic syndrome associated with a factor H mutation : successful treatment with intensive plasma exchanges and ganciclovir / Am J Kidney Dis 45:e12~e15
Hofer J / 2014 / Extra-renal manifestations of complement-mediated thrombotic microangiopathies / Front Pediatr 2:97
Ito S / 2019 / Safety and effectiveness of eculizumab for pediatric patients with atypical hemolytic-uremic syndrome in Japan : interim analysis of post-marketing surveillance / Clin Exp Nephrol 23:112~121
Poornima Ramanan / 2013 / Cytomegalovirus Infections in Solid Organ Transplantation: A Review / Infection and Chemotherapy 45(3):260~271
Olie KH / 2005 / Posttransplantation cytomegalovirus-induced recurrence of atypical hemolytic uremic syndrome associated with a factor H mutation : successful treatment with intensive plasma exchanges and ganciclovir / Am J Kidney Dis 45:e12~e15
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