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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 277 - 281 (5page)
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Cytomegalovirus (CMV) is a well-established cause of morbidity and mortality in pediatric recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT). CD8+ T-cells are important for controlling CMV infection. We conducted a prospective pilot study to investigate the clinical utility of measuring the CMV-specific T-cell immune response using the QuantiFERON-CMV assay (QF-CMV) in pediatric allo-HSCT recipients. Overall, 16 of 25 (64%) patients developed CMV infection. QF-CMV was evaluated in these 16 patients during the early and late phases of the first CMV infection post allo-HSCT. Whereas the initial QF-CMV results during the early phase of CMV infection did not correlate with the course of the corresponding infection, the QF-CMV results post resolution of the first CMV infection correlated with the recurrence of CMV infection until 12 months post allo-HSCT; no recurrent infections occurred in the four QF-CMV-positive patients, while recurrent infections manifested in five of eight QF-CMV-negative (62.5%) and all three QF-CMV-indeterminate patients (P=0.019). In spite of the small number of patients examined, this study supports the potential application of monitoring CMV-specific T-cell immunity using the QF-CMV assay to predict the recurrence of CMV infection in pediatric allo-HSCT recipients.
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참고문헌 (17)
참고문헌 신청
Abate D / 2012 / Diagnostic utility of human cytomegalovirus-specific T-cell response monitoring in predicting viremia in pediatric allogeneic stem-cell transplant patients
Avetisyan G / 2007 / Evaluation of intervention strategy based on CMV-specific immune responses after allogeneic SCT / Bone Marrow Transplant 40 : 865 ~ 869
Boeckh M / 2004 / Recent advances in the prevention of CMV infection and disease after hematopoietic stem cell transplantation / Pediatr Transplant 8 (S5) : S19 ~ S27
Castagnola E / 2004 / Cytomegalovirus infection after bone marrow transplantation in children / Hum Immunol 65 : 416 ~ 422
Crough T / 2009 / Immunobiology of human cytomegalovirus: from bench to bedside / Clin Microbiol Rev 22 : 76 ~ 98
Avetisyan G / 2007 / Evaluation of intervention strategy based on CMV-specific immune responses after allogeneic SCT / Bone Marrow Transplant 40 : 865 ~ 869
Boeckh M / 2004 / Recent advances in the prevention of CMV infection and disease after hematopoietic stem cell transplantation / Pediatr Transplant 8 (S5) : S19 ~ S27
Castagnola E / 2004 / Cytomegalovirus infection after bone marrow transplantation in children / Hum Immunol 65 : 416 ~ 422
Crough T / 2009 / Immunobiology of human cytomegalovirus: from bench to bedside / Clin Microbiol Rev 22 : 76 ~ 98
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