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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 55 - 58 (4page)
- DOI
- 10.34184/kssb.2021.9.3.55
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초록· 키워드
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Receptor-type protein tyrosine phosphatases (RPTPs) belong to the protein tyrosine phosphatase (PTP) family and play a critical role in cell signaling. RPTPH, a type of RPTP, consists of long extracellular domains, a transmembrane domain, and a single intracellular domain with phosphatase activity. RPTPH is involved in phosphorylation of target proteins involved in the AKT signaling pathway and regulates T-cell function and cell apoptosis. The protein is also implicated in progression of colorectal and lung cancers. Despite the importance of RPTPH in tumor-related cell signaling and therapeutic drug development, the structure of this enzyme has not yet been determined. We overexpressed, purified, and crystallized the catalytic domain of RPTPH. The RPTPH crystal diffracted at a resolution of 1.56 A. It belonged to the space group P32 with unit cell parameters a = b = 56.46 A, c = 80.45 A, α = β = 90°, and γ = 120°.
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참고문헌 (17)
참고문헌 신청
Coles, C. H. / 2011 / Proteoglycan-specific molecular switch for RPTPσ clustering and neuronal extension / Science 332:484~488
Doody, K. M. / 2015 / Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy / Sci Transl Med 7:288
Ito, T. / 2003 / Interaction of SAP-1, a transmembrane-type protein-tyrosine phosphatase, with the tyrosine kinase Lck. Roles in regulation of T cell function / J Biol Chem 278:34854~34863
Liebschner, D. / 2019 / Macromolecular structure determination using X-rays, neutrons and electrons : recent developments in Phenix / Acta Crystallogr D Struct Biol 75:861~877
McCoy, A. J. / 2007 / Phaser crystallographic software / J Appl Crystallogr 40:658~674
Doody, K. M. / 2015 / Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy / Sci Transl Med 7:288
Ito, T. / 2003 / Interaction of SAP-1, a transmembrane-type protein-tyrosine phosphatase, with the tyrosine kinase Lck. Roles in regulation of T cell function / J Biol Chem 278:34854~34863
Liebschner, D. / 2019 / Macromolecular structure determination using X-rays, neutrons and electrons : recent developments in Phenix / Acta Crystallogr D Struct Biol 75:861~877
McCoy, A. J. / 2007 / Phaser crystallographic software / J Appl Crystallogr 40:658~674
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