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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.7
- 수록면
- 622 - 630 (9page)
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Leukocyte common antigen-related protein tyrosine phosphatases (LAR-RPTPs) are cellular receptors of heparan sulfate (HS) and chondroitin sulfate (CS) proteoglycans that regulate neurite outgrowth and neuronal regeneration. LAR-RPTPs have also received particular attention as the major presynap-tic hubs for synapse organization through selective binding to numerous postsynaptic adhesion partners. Recent structural studies on LAR-RPTP?mediated trans-synaptic adhesion complexes have provided significant insight into the molecular basis of their specific interactions, the key codes for their selective binding, as well as the higher-order clus-tering of LAR-RPTPs necessary for synaptogenic activity. In this review, we summarize the structures of LAR-RPTPs in complex with various postsynaptic adhesion partners and discuss the molecular mechanisms underlying LAR-RPTP?mediated synaptogenesis.
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참고문헌 (54)
참고문헌 신청
Ammendrup-Johnsen, I. / 2015 / Neurotrophin-3 enhances the synaptic organizing function of TrkC-protein tyrosine phosphatase sigma in rat hippocampal neurons / J. Neurosci. 35:12425~12431
Aricescu, A.R. / 2002 / Heparan sulfate proteoglycans are ligands for receptor protein tyrosine phosphatase sigma / Mol. Cell Biol. 22:1881~1892
Aruga, J. / 2003 / Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowth / Mol. Cell. Neurosci. 24:117~129
Aruga, J. / 2003 / Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue / Gene 315:87~94
Banfield, M.J. / 2001 / Specificity in Trk receptor:neurotrophin interactions: the crystal structure of TrkB-d5 in complex with neurotrophin-4/5 / Structure 9:1191~1199
Aricescu, A.R. / 2002 / Heparan sulfate proteoglycans are ligands for receptor protein tyrosine phosphatase sigma / Mol. Cell Biol. 22:1881~1892
Aruga, J. / 2003 / Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowth / Mol. Cell. Neurosci. 24:117~129
Aruga, J. / 2003 / Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue / Gene 315:87~94
Banfield, M.J. / 2001 / Specificity in Trk receptor:neurotrophin interactions: the crystal structure of TrkB-d5 in complex with neurotrophin-4/5 / Structure 9:1191~1199
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