지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1,035 - 1,045 (11page)
이용수
초록· 키워드
오류제보하기
The Drosophila genome contains four low molecular weightprotein tyrosine phosphatase (LMW-PTP) members: Primo-1, Primo-2, CG14297, and CG31469. The lack of intensive biochemical analysis has limited our understanding of these proteins. Primo-1 and CG31469 were previously classified as pseudophosphatases, but CG31469 was also suggested to be a putative protein arginine phosphatase. Herein, we present the crystal structures of CG31469 and Primo-1, which are the first Drosophila LMW-PTP structures. Structural analysis showed that the two proteins adopt the typical LMW-PTP fold and have a canonically arranged P-loop. Intriguingly, while Primo-1 is presumed to be a canonical LMW-PTP, CG31469 is unique as it contains a threonine residue at the fifth position of the P-loop motif instead of highly conserved isoleucine and a characteristically narrow active site pocket, which should facilitate the accommodation of phosphoarginine. Subsequent biochemical analysis revealed that Primo-1 and CG31469 are enzymatically active on phosphotyrosine and phosphoarginine, respectively, refuting their classification as pseudophosphatases. Collectively, we provide structural and biochemical data on two Drosophila proteins: Primo-1, the canonical LMW-PTP protein, and CG31469, the first investigated eukaryotic protein arginine phosphatase. We named CG31469 as DARP, which stands for Drosophila ARginine Phosphatase.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Adams, P. D. / 2010 / PHENIX : a comprehensive Python-based system for macromolecular structure solution / Acta Crystallogr. D Biol. Crystallogr 66:213~221
Andersen, J. N. / 2001 / Structural and evolutionary relationships among protein tyrosine phosphatase domains / Mol. Cell. Biol 21:7117~7136
Ardito, F. / 2017 / The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy(Review) / Int. J. Mol. Med 40:271~280
Caselli, A. / 2016 / Low molecular weight protein tyrosine phosphatase : Multifaceted functions of an evolutionarily conserved enzyme / Biochim. Biophys. Acta 1864:1339~1355
Elsholz, A. K. / 2012 / Global impact of protein arginine phosphorylation on the physiology of Bacillus subtilis / Proc. Natl. Acad. Sci. U. S. A 109:7451~7456
Andersen, J. N. / 2001 / Structural and evolutionary relationships among protein tyrosine phosphatase domains / Mol. Cell. Biol 21:7117~7136
Ardito, F. / 2017 / The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy(Review) / Int. J. Mol. Med 40:271~280
Caselli, A. / 2016 / Low molecular weight protein tyrosine phosphatase : Multifaceted functions of an evolutionarily conserved enzyme / Biochim. Biophys. Acta 1864:1339~1355
Elsholz, A. K. / 2012 / Global impact of protein arginine phosphorylation on the physiology of Bacillus subtilis / Proc. Natl. Acad. Sci. U. S. A 109:7451~7456
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Structure-Based Virtual Screening of Protein Tyrosine Phosphatase Inhibitors: Significance, Challenges, and Solutions
Journal of Microbiology and Biotechnology
2017 .01
-
Deletion of cg1360 Affects ATP Synthase Function and Enhances Production of L-Valine in Corynebacterium glutamicum
Journal of Microbiology and Biotechnology
2019 .01
-
A novel allosteric inhibitor of protein tyrosine phosphatase sigma
Biodesign
2020 .01
-
Crystal structure of the complex of DUSP15 and its inhibitor reveals novel inhibitor binding interactions
Biodesign
2019 .01
-
The Expression of Human Cathelicidin-Like cg6568 of Drosophila melanogaster is Inhibited by Mycobacterial Infection
한국미생물학회 학술대회논문집
2015 .04
-
PTP포장의 세계시장 동향
포장계
2017 .01
-
Neuroprotective Effects of Protein Tyrosine Phosphatase 1B Inhibition against ER Stress-Induced Toxicity
Molecules and Cells
2017 .04
-
Identification of Undifferentiated Embryonic Cell Transcription Factor 1 as a Potential Substrate of Carboxyl-Terminal Domain Small Phosphatases
대한화학회지
2015 .04
-
Mass Spectrometry-Based Screening Platform Reveals Orco Interactome in Drosophila melanogaster
Molecules and Cells
2018 .02
-
A novel nonsense mutation in NPR2 gene causing Acromesomelic dysplasia, type Maroteaux in a consanguineous family in Southern Punjab (Pakistan)
Genes & Genomics
2020 .01
-
Plant receptor kinases bind and phosphorylate 14-3-3 proteins
Genes & Genomics
2016 .01
-
Fabrication and characterization of CGS / CIGS tandem solar cells by low temperature process
한국진공학회 학술발표회초록집
2016 .08
-
국내 마을상수도 지하수의 우라늄 함량
자원환경지질
2018 .01
-
Protein Phosphatases Involved in Regulating Mitosis: Facts and Hypotheses
Molecules and Cells
2016 .09
-
세계의 포장 - 정제 PTP포장의 압출성을 개선한 시트재료
포장계
2016 .01
-
세계의 포장 - PTP 바코드표시와향후전망
포장계
2016 .01
-
Structural analysis of activity-modulating mutations of DUSP19
Biodesign
2015 .06
-
Protein Phosphatase 1D (PPM1D) Structure Prediction Using Homology Modeling
조선자연과학논문집
2016 .01
-
Anti-Inflammatory and Protein Tyrosine Phosphatase 1B Inhibitory Metabolites from the Antarctic Marine-Derived Fungal Strain Penicillium glabrum SF-7123
극지연구소 초록집
2021 .08
-
항당뇨 효능이 있는 천연물의 탐색 및 활성물질의 분석
생명과학회지
2023 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0