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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 337 - 343 (7page)
- DOI
- 10.12701/yujm.2020.00843
이용수
초록· 키워드
오류제보하기
Background: Chromogranin A (CgA) levels have been reported to predict mortality in patients with heart failure. However, information on the prognostic value and clinical availability of CgA is limited. We compared the prognostic value of CgA to that of previously proven natriuretic peptide biomarkers in patients with acute heart failure.
Methods: We retrospectively evaluated 272 patients (mean age, 68.5±15.6 years; 62.9% male) who underwent CgA test in the acute stage of heart failure hospitalization between June 2017 and June 2018. The median follow-up period was 348 days. Prognosis was assessed using the composite events of 1-year death and heart failure hospitalization.
Results: In-hospital mortality rate during index admission was 7.0% (n=19). During the 1-year follow-up, a composite event rate was observed in 12.1% (n=33) of the patients. The areas under the receiver-operating characteristic curves for predicting 1-year adverse events were 0.737 and 0.697 for N-terminal pro-B-type natriuretic peptide (NT-proBNP) and CgA, respectively. During follow-up, patients with high CgA levels (>158 pmol/L) had worse outcomes than those with low CgA levels (≤158 pmol/L) (85.2% vs. 58.6%, p<0.001). When stratifying the patients into four subgroups based on CgA and NT-proBNP levels, patients with high NT-proBNP and high CgA had the worst outcome. CgA had an incremental prognostic value when added to the combination of NT-proBNP and clinically relevant risk factors.
Conclusion: The prognostic power of CgA was comparable to that of NT-proBNP in patients with acute heart failure. The combination of CgA and NT-proBNP can improve prognosis prediction in these patients.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Benjamin EJ / 2019 / Heart Disease and Stroke Statistics-2019Update : A Report From the American Heart Association / Circulation 139:e56~e528
이상언 / 2017 / Clinical Characteristics and Outcome of Acute Heart Failure in Korea: Results from the Korean Acute Heart Failure Registry (KorAHF) / Korean Circulation Journal 47(3):341~353
안민수 / 2019 / Prognostic Effect of Guideline-Directed Therapy Is More Noticeable Early in the Course of Heart Failure / Journal of Korean Medical Science 34(17):1~12
김민석 / 2017 / Korean Guidelines for Diagnosis and Management of Chronic Heart Failure / Korean Circulation Journal 47(5):555~643
이주희 / 2019 / KSHF Guidelines for the Management of Acute Heart Failure; Part II: Treatment of Acute Heart Failure / Korean Circulation Journal 49(1):22~45
이상언 / 2017 / Clinical Characteristics and Outcome of Acute Heart Failure in Korea: Results from the Korean Acute Heart Failure Registry (KorAHF) / Korean Circulation Journal 47(3):341~353
안민수 / 2019 / Prognostic Effect of Guideline-Directed Therapy Is More Noticeable Early in the Course of Heart Failure / Journal of Korean Medical Science 34(17):1~12
김민석 / 2017 / Korean Guidelines for Diagnosis and Management of Chronic Heart Failure / Korean Circulation Journal 47(5):555~643
이주희 / 2019 / KSHF Guidelines for the Management of Acute Heart Failure; Part II: Treatment of Acute Heart Failure / Korean Circulation Journal 49(1):22~45
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