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자료유형
학술저널
저자정보
이동석 (동국대학교)
저널정보
대한심장학회 Korean Circulation Journal Korean Circulation Journal Vol.45 No.6
발행연도
2015.1
수록면
510 - 515 (6page)

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Background and Objectives: This study aimed to investigate the clinical characteristics of infantile Kawasaki disease (KD), and toevaluate early diagnostic features of KD in febrile infants. Subjects and Methods: We retrospectively reviewed the medical records of 64 KD patients from January 2010 to October 2014. Therewas an analysis of the clinical, laboratory data of the infants versus children groups. Furthermore, the clinical and laboratory data ofinfantile KD patients were compared with 16 infants who were admitted for other acute febrile diseases. Results: A total of 64 patients with KD were identified; 20 (31.3%) were infants; 44 (68.8%) were >1 year old children. Incomplete KDwas much more common in infants (n=13, 65.0%) than in children group (n=14, 31.8%) (p=0.013). The infants were characterized bysignificantly higher rates of inflammatory changes at the Bacille Calmett-Guérin (BCG) inoculation site (p<0.001), but lower rates ofchanges in the extremities (p=0.029) and cervical lymphadenopathy (p=0.006). The serum levels of platelet after 1 week (p=0.005),C-reactive protein (p=0.038), and N-terminal pro-brain natriuretic peptide (NT-proBNP) (p=0.026) were all significantly higher in theinfants group. Comparing the infants with KD versus the other acute febrile diseases, there were significantly higher serum levels oferythrocyte sedimentation rate (p=0.002), C-reactive protein (p=0.046) and NT-proBNP (p=0.001) for the infants with KD group. Conclusion: BCGitis and higher levels of NT-proBNP can be helpful for early diagnosis of the incomplete KD in infants, and may be agood predictor of KD in acute febrile infants, when combined with other acute phase reactants.

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