지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
A 44-year-old male patient with a 15-year history of plaque-type psoriasis visited our dermatologic clinic. In screening tests for latent tuberculosis (TB) infection, both interferon-gamma release assay and purified protein derivative skin test showed positive results. As chest radiography showed no specific findings and the patient had no respiratory symptoms, isoniazid was administered for 9 months. For the treatment of psoriasis, ustekinumab was started. The patient was treated with ustekinumab for 5 years followed by secukinumab for 47 weeks. Thereafter, owing to a decrease in drug efficacy, guselkumab was started. At 21 weeks after treatment with guselkumab, a chest radiograph showed findings suspicious for TB. Subsequent chest computed tomography revealed active TB, and the patient was referred to a pulmonologist for further evaluation. Biologics are considered safe for the treatment of psoriasis. However, in patients with long-term administration of multiple biologics, the risk of TB reactivation should not be overlooked.
목차
등록된 정보가 없습니다.
참고문헌 (12)
참고문헌 신청
Min Seok Hur / 2020 / Clinical characteristics of psoriatic patients with latent tuberculosis infection / European Journal of Dermatology 30(2):127~132
Snast I / 2019 / Active Tuberculosis in Patients with Psoriasis Receiving Biologic Therapy : A Systematic Review / Am J Clin Dermatol 20(4):483~491
Zhang Z / 2017 / Risk of tuberculosis in patients treated with TNF- antagonists : a systematic review and meta-analysis of randomised controlled trials / BMJ Open 7:1~8
오재홍 / 2021 / Disseminated Tuberculosis in a Psoriasis Patient under Adalimumab Treatment despite the Chemoprophylaxis of Latent Tuberculosis: A Case Report / Annals of Dermatology 33(1):77~81
Fowler E / 2020 / Risk of tuberculosis reactivation during interleukin-17 inhibitor therapy for psoriasis : a systematic review / J Eur Acad Dermatol Venereol 34(7):1449~1456
Snast I / 2019 / Active Tuberculosis in Patients with Psoriasis Receiving Biologic Therapy : A Systematic Review / Am J Clin Dermatol 20(4):483~491
Zhang Z / 2017 / Risk of tuberculosis in patients treated with TNF- antagonists : a systematic review and meta-analysis of randomised controlled trials / BMJ Open 7:1~8
오재홍 / 2021 / Disseminated Tuberculosis in a Psoriasis Patient under Adalimumab Treatment despite the Chemoprophylaxis of Latent Tuberculosis: A Case Report / Annals of Dermatology 33(1):77~81
Fowler E / 2020 / Risk of tuberculosis reactivation during interleukin-17 inhibitor therapy for psoriasis : a systematic review / J Eur Acad Dermatol Venereol 34(7):1449~1456
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