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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 685 - 698 (14page)
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The advent of biologics and biologic therapy has transformed the management of inflammatory bowel disease (IBD) with enhanced early and adequate responses to treatment, fewer hospitalizations, a reduced need for surgery, and unprecedented outcomes including complete mucosal and histologic healing. However, an important issue with the use of anti-tumor necrosis factor (anti-TNF) agents in IBD is the increased risk of tuberculosis (TB). This is compounded by the diagnostic dilemma when differentiating between Crohn’s disease and gastrointestinal TB, and the potentially serious consequences of initiating an incorrect treatment in the case of misdiagnosis. The interplay between IBD and TB is most relevant in Asia, where more than 60% of the 10.4 million new TB cases in 2016 were reported. A number of studies have reported an increased risk of TB with anti-TNF agents, including in patients who had tested negative for TB prior to treatment initiation. The limited evidence currently available regarding adhesion molecule antagonists such as vedolizumab suggests a comparatively lower risk of TB, thus making them a promising option for IBD management in TBendemic regions. This comprehensive review examines the available literature on the risk of TB with the use of biologics in the TB-endemic regions of Asia, focusing on the diagnostic dilemma, the risk of reactivation, and the optimized management algorithms for latent and active disease.
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참고문헌 (76)
참고문헌 신청
Podolsky DK / 2002 / Inflammatory bowel disease / N Engl J Med 347:417~429
Bernstein CN / 2016 / World Gastroenterology Organisation Global Guidelines Inflammatory Bowel Disease : update august 2015 / J Clin Gastroenterol 50:803~818
Ananthakrishnan AN / 2015 / Epidemiology and risk factors for IBD / Nat Rev Gastroenterol Hepatol 12:205~217
Silverberg MS / 2005 / Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology / Can J Gastroenterol 19(Suppl A):5A~36A
Satsangi J / 2006 / The Montreal classification of inflammatory bowel disease : controversies, consensus, and implications / Gut 55:749~753
Bernstein CN / 2016 / World Gastroenterology Organisation Global Guidelines Inflammatory Bowel Disease : update august 2015 / J Clin Gastroenterol 50:803~818
Ananthakrishnan AN / 2015 / Epidemiology and risk factors for IBD / Nat Rev Gastroenterol Hepatol 12:205~217
Silverberg MS / 2005 / Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology / Can J Gastroenterol 19(Suppl A):5A~36A
Satsangi J / 2006 / The Montreal classification of inflammatory bowel disease : controversies, consensus, and implications / Gut 55:749~753
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