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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 123 - 129 (7page)
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Background and Objectives: Hypermethylation of the tumor suppressor gene RASSF1A and activating mutation of BRAF gene have been recently reported in thyroid cancers. To investigate the role of these two epigenetic and genetic alterations in thyroid tumor progression, methylation of RASSF1A and BRAF mutation were examined in thyroid tumors. Materials and Methods: During 2007 to 2017, 69 papillary carcinomas, 18 nodular hyperplasia, 3 follicular carcinomas, and 13 follicular adenomas were selected. The methylation-specific polymerase chain reaction (MSP) technique was used in detecting RASSF1A methylation and polymerase chain reaction (PCR)-single-stranded conformation polymorphism and sequencing were used for BRAF gene mutation study. Results: The hypermethylation of the RASSF1A gene was found in 84.6%, 100% and 57.9% of follicular adenomas, follicular carcinomas, and papillary carcinomas, respectively. Nodular hyperplasia showed a hypermethylation in 33.3%. The BRAF mutation at V600E was found in 60.7% of papillary carcinoma and 27.0% of nodular hyperplasia, but none of follicular neoplasms. The BRAF mutation was correlated with the lymph node metastasis and MACIS clinical stage. There is an inverse correlation between RASSF1A methylation and BRAF mutation in thyroid lesions. Conclusion: Epigenetic inactivation of RASSF1A through aberrant methylation is considered to be an early step in thyroid tumorigenesis, and the BRAF mutation plays an important role in the carcinogenesis of papillary carcinoma, providing a genetic marker.
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참고문헌 (24)
참고문헌 신청
Ministry of Health / 2017 / Anual report of cancer statistics in Korea in 2017
Baylin SB / 2002 / Mechanisms underlying epigenetically mediated gene silencing in cancer / Semin Cancer Biol 12(5):331~337
Kimura ET / 2003 / High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma / Cancer Res 63(7):1454~1457
Moretti F / 2000 / Molecular pathogenesis of thyroid nodules and cancer / Baillieres Best Pract Res Clin Endocrinol Metab 14(4):517~539
Soares P / 2003 / BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC / Oncogene 22(29):4578~4580
Baylin SB / 2002 / Mechanisms underlying epigenetically mediated gene silencing in cancer / Semin Cancer Biol 12(5):331~337
Kimura ET / 2003 / High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma / Cancer Res 63(7):1454~1457
Moretti F / 2000 / Molecular pathogenesis of thyroid nodules and cancer / Baillieres Best Pract Res Clin Endocrinol Metab 14(4):517~539
Soares P / 2003 / BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC / Oncogene 22(29):4578~4580
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BRAF Mutation Status and Clinicopathologic Characteristics in Colorectal Adenocarcinoma
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Prediction Table and Nomogram as Tools for Diagnosis of Papillary Thyroid Carcinoma : Combined Analysis of Ultrasonography, Fine Needle Aspiration Biopsy, and BRAF V600E Mutation
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Clinicopathologic Significance of BRAF Mutation and Extracellular Signal Regulated Kinase 1/2 Expression in Patients With a Colorectal Adenocarcinoma
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KRAS, NRAS, and BRAF mutations in plasma cell myeloma at a single Korean institute
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