지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 470 - 475 (6page)
이용수
초록· 키워드
오류제보하기
Low-dose metronomic chemotherapy has been introduced as aless toxic and effective strategy to inhibit tumor angiogenesis,but its anti-angiogenic mechanism on endothelial progenitorcells (EPCs) has not been fully elucidated. Here, we investigatedthe functional role of regulated in development and DNA damageresponse 1 (REDD1), an endogenous inhibitor of mTORC1,in low-dose doxorubicin (DOX)-mediated dysregulation of EPCfunctions. DOX treatment induced REDD1 expression in bonemarrow mononuclear cells (BMMNCs) and subsequently reducedmTORC1-dependent translation of endothelial growth factor(VEGF) receptor (Vegfr)-2 mRNA, but not that of the mRNAtranscripts for Vegfr-1, epidermal growth factor receptor, andinsulin-like growth factor-1 receptor. This selective event was arisk factor for the inhibition of BMMNC differentiation intoEPCs and their angiogenic responses to VEGF-A, but was notobserved in Redd1-deficient BMMNCs. Low-dose metronomicDOX treatment reduced the mobilization of circulating EPCsin B16 melanoma-bearing wild-type but not Redd1-deficientmice. However, REDD1 overexpression inhibited the differentiationand mobilization of EPCs in both wild-type and Redd1-deficient mice. These data suggest that REDD1 is crucial formetronomic DOX-mediated EPC dysfunction through the translationalrepression of Vegfr-2 transcript, providing REDD1 as apotential therapeutic target for the inhibition of tumor angiogenesisand tumor progression.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Shibuya M / 2011 / Vascular endothelial growth factor(VEGF)and its receptor(VEGFR)signaling in angiogenesis : a crucial target for anti-and pro-angiogenic therapies / Genes Cancer 2:1097~1105
Beck B / 2011 / A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours / Nature 478:399~403
Ji Yoon Kim / 2019 / Tumor endothelial cells as a potential target of metronomic chemotherapy / Archives of Pharmacal Research 42(1):1~13
Kerbel RS / 2008 / Tumor angiogenesis / N Engl J Med 358:2039~2049
Stoelting S / 2008 / Low-dose oral metronomic chemotherapy prevents mobilization of endothelial progenitor cells into the blood of cancer patients / In Vivo 22:831~836
Beck B / 2011 / A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours / Nature 478:399~403
Ji Yoon Kim / 2019 / Tumor endothelial cells as a potential target of metronomic chemotherapy / Archives of Pharmacal Research 42(1):1~13
Kerbel RS / 2008 / Tumor angiogenesis / N Engl J Med 358:2039~2049
Stoelting S / 2008 / Low-dose oral metronomic chemotherapy prevents mobilization of endothelial progenitor cells into the blood of cancer patients / In Vivo 22:831~836
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
REDD1 is a determinant of low-dose metronomic doxorubicin-elicited endothelial cell dysfunction through downregulation of VEGFR-2/3 expression
Experimental and Molecular Medicine
2021 .10
-
토지이용변화에 따른 온실가스 배출량 분석 : REDD+ 사업을 중심으로
한국에너지기후변화학회 학술대회
2017 .11
-
OCO-2를 활용한 REDD 사업성과 평가: 에티오피아를 사례로
대한공간정보학회 학술대회
2017 .10
-
Structure and function of vascular endothelial growth factor and its receptor system
BMB Reports
2018 .01
-
Role of Stromal Cell-Derived Factor-1 in Endothelial Progenitor Cell-Mediated Vascular Repair and Regeneration
조직공학과 재생의학
2021 .10
-
NF-κB-dependent miR-31/155 biogenesis is essential for TNF-α-induced impairment of endothelial progenitor cell function
Experimental and Molecular Medicine
2020 .08
-
Mobile EPC for the Public Safety Broadband Network
한국정보과학회 학술발표논문집
2015 .06
-
EPC기업이 엔지니어링 산업의 고용 및 정책에 미친 영향
한국산학기술학회 논문지
2023 .02
-
EPC 계약 문서 자동 분석을 위한 텍스트 데이터 가공 방법 개발
한국정밀공학회 학술발표대회 논문집
2023 .11
-
Loss of phospholipase D2 impairs VEGF-induced angiogenesis
BMB Reports
2016 .01
-
PD-L1-Targeted Doxorubicin Delivery Using Glycol Chitosan Nanoparticles for Synergistic Cancer Chemoimmunotherapy
한국고분자학회 학술대회 연구논문 초록집
2021 .10
-
플랜트 EPC 사업을 위한 구매엔지니어링 관리 지원 시스템 개발
대한기계학회 춘추학술대회
2019 .05
-
Hhip regulates tumor-stroma-mediated upregulation of tumor angiogenesis
Experimental and Molecular Medicine
2017 .01
-
Proposal and Validation of a Series Hybrid System Using a DC-Input Direct Electric-Power Converter D-EPC
ICPE(ISPE)논문집
2023 .05
-
플랜트 EPC, 과거 현재 그리고 미래
대한기계학회 춘추학술대회
2021 .05
-
AHP기법을 통한 EPC기업의 프로젝트 핵심성공프로세스 개발
한국경영공학회지
2020 .01
-
Endothelial miR-26a regulates VEGF-Nogo-B receptor-mediated angiogenesis
BMB Reports
2017 .07
-
Reduction of Energy and Food Security in DPRK due to Deforestation
에너지공학
2018 .09
-
Imaging-guided Drug Delivery via in vivo Copper-free Clicked Clusters of Quantum Dot and Dual Responsive Self-assembled Doxorubicin Nanoparticles
한국고분자학회 학술대회 연구논문 초록집
2021 .04
-
Vascular Endothelial Growth Factor Enhances Axonal Outgrowth in Organotypic Spinal Cord Slices via Vascular Endothelial Growth Factor Receptor 1 and 2
조직공학과 재생의학
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0