개인구독
소속 기관이 없으신 경우, 개인 정기구독을 하시면 저렴하게
논문을 무제한 열람 이용할 수 있어요.
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 439 - 450 (12page)
이용수
초록· 키워드
오류제보하기
Translating ribosomes accompany co-translational regulationof nascent polypeptide chains, including subcellular targeting,protein folding, and covalent modifications. Ribosome-associatedquality control (RQC) is a co-translational surveillance mechanismtriggered by ribosomal collisions, an indication of atypical translation.
The ribosome-associated E3 ligase ZNF598 ubiquitinatessmall subunit proteins at the stalled ribosomes. A series of RQCfactors are then recruited to dissociate and triage aberrant translationintermediates. Regulatory ribosomal stalling may occur onendogenous transcripts for quality gene expression, whereas ribosomalcollisions are more globally induced by ribotoxic stressorssuch as translation inhibitors, ribotoxins, and UV radiation. Thelatter are sensed by ribosome-associated kinases GCN2 andZAKα, activating integrated stress response (ISR) and ribotoxicstress response (RSR), respectively. Hierarchical crosstalks amongRQC, ISR, and RSR pathways are readily detectable since thecollided ribosome is their common substrate for activation. Giventhe strong implications of RQC factors in neuronal physiologyand neurological disorders, the interplay between RQC andribosome-associated stress signaling may sustain proteostasis,adaptively determine cell fate, and contribute to neural pathogenesis.
The elucidation of underlying molecular principles inrelevant human diseases should thus provide unexplored therapeuticopportunities.
목차
등록된 정보가 없습니다.
참고문헌 (123)
참고문헌 신청
Collart MA / 2020 / Ribosome pausing, a dangerous necessity for co-translational events / Nucleic Acids Res 48:1043~1055
Stein KC / 2019 / The stop-and-go traffic regulating protein biogenesis : how translation kinetics controls proteostasis / J Biol Chem 294:2076~2084
D’Orazio KN / 2021 / Ribosome states signal RNA quality control / Mol Cell 81:1372~1383
Wolin SL / 2019 / Cellular RNA surveillance in health and disease / Science 366:822~827
Brandman O / 2016 / Ribosome-associated protein quality control / Nat Struct Mol Biol 23:7~15
Stein KC / 2019 / The stop-and-go traffic regulating protein biogenesis : how translation kinetics controls proteostasis / J Biol Chem 294:2076~2084
D’Orazio KN / 2021 / Ribosome states signal RNA quality control / Mol Cell 81:1372~1383
Wolin SL / 2019 / Cellular RNA surveillance in health and disease / Science 366:822~827
Brandman O / 2016 / Ribosome-associated protein quality control / Nat Struct Mol Biol 23:7~15
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Attenuation of Gene Expression Couplings Through the Dynamic Allocation of Orthogonal ribosomes
한국생물공학회 학술대회
2022 .04
-
Ribosome Synthesis Modeling and Current Bioprocess Development (In memory of Professor Yun and his Ph.D. works)
한국생물공학회 학술대회
2019 .10
-
JNK activation induced by ribotoxic stress is initiated from 80S monosomes but not polysomes
BMB Reports
2019 .01
-
Ribosome-Mediated Biosynthesis of 5- and 6-Membered Ring Oligomers in vitro
한국생물공학회 학술대회
2023 .04
-
Engineering Molecular Translation Systems
한국생물공학회 학술대회
2022 .04
-
Ribosome-mediated Biosynthesis of Pharmacophore
한국생물공학회 학술대회
2023 .04
-
Ribosome-dependent Growth Inhibition by YhaV in Escherichia coli
한국생물공학회 학술대회
2015 .10
-
Purification of Escherichia coli Ribosome by Strong Anion Exchange Spin Columns
한국생물공학회 학술대회
2023 .10
-
Two distinct nodes of translational inhibition in the Integrated Stress Response
BMB Reports
2017 .01
-
Ribosome-Mediated Synthesis of Mirror Image Proteins in vitro
한국생물공학회 학술대회
2024 .09
-
Oxidative damage-induced hyperactive ribosome biogenesis participates in tumorigenesis of offspring by cross-interacting with the Wnt and TGF-β1 pathways in IVF embryos
Experimental and Molecular Medicine
2021 .11
-
Gene repressive mechanisms in the mouse brain involved in memory formation
BMB Reports
2016 .01
-
RQC와 ROLLO에서의 부호 기반 덧셈 동형 암호
한국통신학회 학술대회논문집
2020 .02
-
Modulating cellular balance of Rps3 mono-ubiquitination by both Hel2 E3 ligase and Ubp3 deubiquitinase regulates protein quality control
Experimental and Molecular Medicine
2017 .01
-
Single-molecule visualization of mRNA circularization during translation
Experimental and Molecular Medicine
2023 .01
-
Development of a MALDI-TOF MS-Based System for Detecting Unnatural Amino Acid Incorporation
한국생물공학회 학술대회
2023 .10
-
Phosphorylation of rpS3 by Lyn increases translation of Multi-Drug Resistance (MDR1) gene
BMB Reports
2023 .05
-
Translational control of mRNAs by 3’-Untranslated region binding proteins
BMB Reports
2017 .01
-
Improvement of Human Erythropoietin Expression by IRES- mediated Multicistronic Vector in Chinese Hamster Ovary Cells
한국생물공학회 학술대회
2015 .04
-
Transcriptome and Translatome Profiles of Streptomyces Species in Different Growth Phases
한국생물공학회 학술대회
2022 .09
이 논문의 저자 정보
최근 본 자료
댓글(0)
0