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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 539 - 545 (7page)
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The Integrated Stress Response (ISR) refers to a signaling pathway initiated by stress-activated eIF2α kinases. Once activated, the pathway causes attenuation of global mRNA translation while also paradoxically inducing stress response gene expression. A detailed analysis of this pathway has helped us better understand how stressed cells coordinate gene expression at translational and transcriptional levels. The translational attenuation associated with this pathway has been largely attributed to the phosphorylation of the translational initiation factor eIF2α. However, independent studies are now pointing to a second translational regulation step involving a downstream ISR target, 4E-BP, in the inhibition of eIF4E and specifically cap-dependent translation. The activation of 4E-BP is consistent with previous reports implicating the roles of 4E-BP resistant, Internal Ribosome Entry Site (IRES) dependent translation in ISR active cells. In this review, we provide an overview of the translation inhibition mechanisms engaged by the ISR and how they impact the translation of stress response genes.
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참고문헌 (24)
참고문헌 신청
Andreev DE / 2015 / Translation of 5' leaders is pervasive in genes resistant to eIF2 repression / eLife 4 : e03971 ~
Baird TD / 2014 / Selective mRNA translation during eIF2 phosphorylation induces expression of IBTKalpha / Mol Biol Cell 25 : 1686 ~ 1697
Chang KJ / 2004 / Translation initiation from a naturally occurring non-AUG codon in Saccharomyces cerevisiae / J Biol Chem 279 : 13778 ~ 13785
Dever TE / 1992 / Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates genespecific translational control of GCN4 in yeast / Cell 68 : 585 ~ 596
Dmitriev SE / 2010 / GTP-independent tRNA delivery to the ribosomal P-site by a novel eukaryotic translation factor / J Biol Chem 285 : 26779 ~ 26787
Baird TD / 2014 / Selective mRNA translation during eIF2 phosphorylation induces expression of IBTKalpha / Mol Biol Cell 25 : 1686 ~ 1697
Chang KJ / 2004 / Translation initiation from a naturally occurring non-AUG codon in Saccharomyces cerevisiae / J Biol Chem 279 : 13778 ~ 13785
Dever TE / 1992 / Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates genespecific translational control of GCN4 in yeast / Cell 68 : 585 ~ 596
Dmitriev SE / 2010 / GTP-independent tRNA delivery to the ribosomal P-site by a novel eukaryotic translation factor / J Biol Chem 285 : 26779 ~ 26787
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