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- 학술저널
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- 2017.1
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When a ribosome complex is stalled during the translation elongation process in eukaryotes, the mono-ubiquitination of Rps3 has recently been shown to be critical to ribosome quality control. We have discovered that the regulatory role of Rps3 mono-ubiquitination is controlled by a deubiquitinase. We also showed that an autophagic signal appears to be coupled to the mono-ubiquitination of Rps3p through the entrance of Ubp3p into the autophagosome in yeasts. The mono-ubiquitination of the Rps3 protein is tightly modulated by reciprocal action between the Hel2p E3 ligase and the Ubp3p deubiquitinase in yeasts and the reciprocal action between the RNF123 E3 ligase and the USP10 deubiquitinase in mammalian cells. We also found that the Ubp3p/USP10 deubiquitinases critically modulate Hel2p/RNF123-mediated Rps3p mono-ubiquitination. In addition, we found that Hel2p/RNF123 and Ubp3p/USP10 appeared to be differently localized in the ribosome complex after ultraviolet irradiation.
Together, our results support a model in which coordinated ubiquitination and deubiquitination activities can finely balance the level of regulatory Rps3p mono-ubiquitination in ribosome-associated quality control and autophagy processes.
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참고문헌 (25)
참고문헌 신청
Denison C / 2005 / Proteomic insights into ubiquitin and ubiquitin-like proteins / Curr Opin Chem Biol 9 : 69 ~ 75
Deutsch WA / 1997 / Characterization and mechanism of action of Drosophila ribosomal protein S3 DNA glycosylase activity for the removal of oxidatively damaged DNA bases / J
Diaz JJ / 2002 / Alteration of ribosomal protein maps in herpes simplex virus type 1 infection / J Chromatogr B Analyt Technol Biomed Life Sci 771 : 237 ~ 249
Fumagalli S / 2009 / Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53induction / Nat Cell B
Ghalei H / 2015 / Hrr25/CK1delta-directed release of Ltv1 from pre-40S ribosomes is necessary for ribosome assembly and cell growth / J Cell Biol 208 : 745 ~ 759
Deutsch WA / 1997 / Characterization and mechanism of action of Drosophila ribosomal protein S3 DNA glycosylase activity for the removal of oxidatively damaged DNA bases / J
Diaz JJ / 2002 / Alteration of ribosomal protein maps in herpes simplex virus type 1 infection / J Chromatogr B Analyt Technol Biomed Life Sci 771 : 237 ~ 249
Fumagalli S / 2009 / Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53induction / Nat Cell B
Ghalei H / 2015 / Hrr25/CK1delta-directed release of Ltv1 from pre-40S ribosomes is necessary for ribosome assembly and cell growth / J Cell Biol 208 : 745 ~ 759
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