지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.7
- 수록면
- 287 - 292 (6page)
- DOI
- https://doi.org/10.3988/jcn.2017.13.3.287
이용수
초록· 키워드
오류제보하기
Background and Purpose Responses to repetitive nerve stimulation (RNS) in patients with muscle-specific tyrosine kinase (MuSK) antibody (Ab)-positive myasthenia gravis (MG) vary depending on the muscles tested. We analyzed the RNS responses of limb and facial muscles in MuSK-Ab-positive and acetylcholine receptor (AChR)-Ab-negative MG (MuSK MG) and MuSK-Ab-negative and AChR-Ab-negative [double-seronegative (DSN)] MG patients.
Methods We retrospectively compared RNS responses between 45 MuSK MG and 29 DSN MG. RNS was applied to the abductor digiti minimi, flexor carpi ulnaris, trapezius, orbicularis oculi, and nasalis muscles.
Results Abnormal RNS responses in limb muscles were observed in 22.2 and 58.6% of MuSK MG and DSN MG patients, respectively, with abnormal facial responses observed in 77.8 and 65.5%, and abnormal responses observed in any of the five muscles in 86.7 and 72.4%. Abnormal RNS responses in the abductor digiti minimi or flexor carpi ulnaris were less frequent in MuSK MG (8.9 and 15.6%, respectively) than in DSN MG (37.9 and 55.2%), whereas the findings for other muscles were not significantly different between the groups. Abnormal facial responses but normal limb responses were independently associated with MuSK MG (odds ratio=5.224, 95% confidence interval=1.300?20.990).
Conclusions Abnormal RNS responses primarily in facial muscles without involvement of limb muscles were more pronounced in MuSK MG than in DSN MG. RNS of both facial and limb muscles in AChR-Ab-negative MG can increase the test sensitivity and aid in early suspicion of MuSK MG.
목차
등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Gilhus NE / 2016 / Myasthenia gravis / N Engl J Med 375:2570~2581
김승민 / 2016 / The Epidemiology of Myasthenia Gravis in Korea / Yonsei Medical Journal 57(2):419~425
Evoli A / 2003 / Clinical correlates with anti-MuSK antibodies in generalized seronegative myasthenia gravis / Brain 126(Pt 10):2304~2311
Hoch W / 2001 / Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies / Nat Med 7:365~368
Lavrnic D / 2005 / The features of myasthenia gravis with autoantibodies to MuSK / J Neurol Neurosurg Psychiatry 76:1099~1102
김승민 / 2016 / The Epidemiology of Myasthenia Gravis in Korea / Yonsei Medical Journal 57(2):419~425
Evoli A / 2003 / Clinical correlates with anti-MuSK antibodies in generalized seronegative myasthenia gravis / Brain 126(Pt 10):2304~2311
Hoch W / 2001 / Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies / Nat Med 7:365~368
Lavrnic D / 2005 / The features of myasthenia gravis with autoantibodies to MuSK / J Neurol Neurosurg Psychiatry 76:1099~1102
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