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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 613 - 619 (7page)
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초록· 키워드
오류제보하기
Objective We aimed to explore the impact of moderate intensity exercise on the cortical thickness and subcortical volumes of preclinical Alzheimer’s disease (AD) patients.Methods Sixty-three preclinical AD patients with magnetic resonance imaging (MRI) and 18-florbetaben positron emission tomography (PET) data were enrolled in the study. Information on demographic characteristics, cognitive battery scores, self-reported exercise habits were attained. Structural magnetic resonance images were analyzed and processed using Freesurfer v6.0.Results Compared to Exercise group, Non-Exercise group demonstrated reduced cortical thickness in left parstriangularis, rostral middle frontal, entorhinal, superior frontal, lingual, superior parietal, lateral occipital, inferior parietal gyrus, temporal pole, precuneus, insula, fusiform gyrus, right precuneus, superiorparietal, lateral orbitofrontal, rostral middle frontal, medial orbitofrontal, superior frontal, lingual, middle temporal gyrus, insula, supramarginal, parahippocampal, paracentral gyrus. Volumes of right thalamus, caudate, putamen, pallidum, hippocampus, amygdala were also reduced in Non-Exercise group.Conclusion Moderate intensity exercise affects cortical and subcortical structures in preclinical AD patients. Thus, physical exercise has a potential to be an effective intervention to prevent future cognitive decline in those at high risk of AD.
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참고문헌 (50)
참고문헌 신청
2019 / Global, regional, and national burden of Alzheimer’s disease and other dementias, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016 / Lancet Neurol 18:88~106
Pereira CF / 2019 / Is Alzheimer’s disease an inflammasomopathy? / Ageing Res Rev 56:100966
Gong CX / 2018 / Multifactorial hypothesis and multi-targets for Alzheimer’s disease / J Alzheimers Dis 64:S107~S117
Armstrong RA / 2019 / Risk factors for Alzheimer’s disease / Folia Neuropathol 57:87~105
Kivipelto M / 2018 / Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease / Nat Rev Neurol 14:653~666
Pereira CF / 2019 / Is Alzheimer’s disease an inflammasomopathy? / Ageing Res Rev 56:100966
Gong CX / 2018 / Multifactorial hypothesis and multi-targets for Alzheimer’s disease / J Alzheimers Dis 64:S107~S117
Armstrong RA / 2019 / Risk factors for Alzheimer’s disease / Folia Neuropathol 57:87~105
Kivipelto M / 2018 / Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease / Nat Rev Neurol 14:653~666
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